Chen Yun-Chi, Zavala Fidel
Department of Molecular Microbiology and Immunology, John Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Methods Mol Biol. 2013;923:481-91. doi: 10.1007/978-1-62703-026-7_33.
T-cell receptor transgenic mice are powerful tools to study T cell responses to malaria parasites. They allow for a population of antigen specific T cells to be monitored during developing responses to immunization or parasite infection; this makes them particularly useful to study fundamental aspects of T cell activation, differentiation, and migration in different tissue compartments. Moreover, the use of these cells allows for a thorough analysis of the mechanisms of antiparasite activity by T cells.
T细胞受体转基因小鼠是研究T细胞对疟原虫反应的有力工具。它们能够在免疫或寄生虫感染的反应发展过程中监测一群抗原特异性T细胞；这使得它们在研究不同组织区室中T细胞活化、分化和迁移的基本方面特别有用。此外，使用这些细胞能够对T细胞的抗寄生虫活性机制进行全面分析。
