Transplant Infectious Diseases, Alberta Transplant Institute, University of Alberta, Edmonton, Canada.
Clin Infect Dis. 2012 Dec;55(12):1678-89. doi: 10.1093/cid/cis818. Epub 2012 Sep 18.
Cytomegalovirus (CMV) is one of the most common infections after solid organ transplantation. Improved assays to predict viral replication and disease would help refine current preventive strategies. Monitoring of CMV-specific T-cell responses may help guide clinical decision making. Several techniques are now available to quantify CMV-specific T-cell responses, including flow cytometry, enzyme-linked immunosorbent spot assay, and enzyme-linked immunosorbent assay. Standardization and validation of these assays have the potential to significantly change the monitoring and treatment of CMV and further personalize CMV prevention strategies. In this review, we discuss the measurement of CMV-specific T-cell responses and their clinical impact on the management of CMV after organ transplantation.
巨细胞病毒（CMV）是实体器官移植后最常见的感染之一。改进预测病毒复制和疾病的检测方法将有助于完善当前的预防策略。监测 CMV 特异性 T 细胞反应可能有助于指导临床决策。目前有几种技术可用于定量 CMV 特异性 T 细胞反应，包括流式细胞术、酶联免疫斑点法和酶联免疫吸附试验。这些检测方法的标准化和验证有可能显著改变 CMV 的监测和治疗，并进一步实现 CMV 预防策略的个体化。在这篇综述中，我们讨论了 CMV 特异性 T 细胞反应的测量及其对器官移植后 CMV 管理的临床影响。
