Ahmed Adamu, Ukwenya Yahaya, Abdullahi Adamu, Muhammad Iliyasu
Department of Surgery, Ahmadu Bello University Teaching Hospital, Zaria, Nigeria.
Int J Breast Cancer. 2012;2012:845143. doi: 10.1155/2012/845143. Epub 2012 Sep 6.
Male breast cancer is an uncommon disease accounting for only 1% of all breast cancers. We present the evaluation, treatment and outcome of male patients seen with breast cancer in our institution. Male patients that had histological diagnosis of breast cancer from 2001 to 2010 were retrospectively evaluated. After evaluation patients were treated with modified radical mastectomy. Combination chemotherapy was given to patients with positive axillary lymph nodes. Radiotherapy and hormonal therapy were also employed. There were 57 male patients with breast cancer which accounted for 9% of all breast cancers seen during the study period. Their mean age was 59 ± 2.3 years. The mean tumor diameter was 13 ± 2.5 cm. Fifty three (93%) patients presented with advanced disease including 15 with distant metastasis. Four patients with stage II disease were treated with modified radical mastectomy, chemotherapy and tamoxifen. Of the 30 patients with sage III disease that had modified radical mastectomy, complete axillary clearance and tumor free margins were achieved in 25. Overall 21 (36.8%) patients were tumor free at one year. Overall 5-year survival was 22.8%. In conclusion, male patients with breast cancer present with advanced disease which is associated with poor outcome of treatment.
男性乳腺癌是一种罕见疾病,仅占所有乳腺癌的1%。我们介绍了在我们机构就诊的男性乳腺癌患者的评估、治疗及预后情况。对2001年至2010年间经组织学诊断为乳腺癌的男性患者进行了回顾性评估。评估后,患者接受了改良根治性乳房切除术。腋窝淋巴结阳性的患者接受了联合化疗。还采用了放疗和激素治疗。共有57例男性乳腺癌患者,占研究期间所见所有乳腺癌患者的9%。他们的平均年龄为59±2.3岁。平均肿瘤直径为13±2.5厘米。53例(93%)患者表现为晚期疾病,其中15例有远处转移。4例II期疾病患者接受了改良根治性乳房切除术、化疗和他莫昔芬治疗。在30例行改良根治性乳房切除术的III期疾病患者中,25例实现了腋窝完全清扫且切缘无肿瘤。总体而言,21例(36.8%)患者在1年后无肿瘤。总体5年生存率为22.8%。总之,男性乳腺癌患者表现为晚期疾病,这与治疗效果不佳相关。