Shehabi A, Shakir K, el-Khateeb M, Qubain H, Fararjeh N, Shamat A R
Department of Microbiology, University of Jordan, Faculty of Medicine, Amman.
J Infect. 1990 Jan;20(1):5-10. doi: 10.1016/s0163-4453(90)92214-6.
During the year 1987, 106 cases of human brucellosis were studied prospectively at the Jordan University Hospital. The disease was more often diagnosed among adults (73.6%) than children (26.4%). Serious clinical complications were observed in 5.7% patients. An initial Brucella antibody titre greater than or equal to 160 proved to be reliable in confirming suspected cases of acute and subacute brucellosis. Culture of blood was found to be more sensitive (44.4%) and significant (P less than 0.02) than bone marrow culture (27.7%) for detecting Brucella melitensis. All patients treated with rifampicin plus tetracycline or co-trimoxazole were considered to be clinically cured by disappearance of all major clinical features of brucellosis. By contrast, 2/10 patients treated with rifampicin alone, as well as 1/56 patients treated with tetracycline and streptomycin, clinically relapsed. It is evident from this study that the treatment with rifampicin alone is not as effective in brucellosis as it is when given with another appropriate drug.
1987年期间，约旦大学医院对106例人类布鲁氏菌病患者进行了前瞻性研究。该疾病在成年人中的诊断率（73.6%）高于儿童（26.4%）。5.7%的患者出现了严重的临床并发症。布鲁氏菌抗体初始滴度大于或等于160被证明在确诊急性和亚急性布鲁氏菌病疑似病例方面是可靠的。在检测羊布鲁氏菌时，血液培养比骨髓培养更敏感（44.4%）且差异有统计学意义（P<0.02），骨髓培养的阳性率为27.7%。所有接受利福平加四环素或复方新诺明治疗的患者，随着布鲁氏菌病所有主要临床特征的消失，均被认为临床治愈。相比之下，单独接受利福平治疗的10例患者中有2例以及接受四环素和链霉素治疗的56例患者中有1例出现了临床复发。从这项研究可以明显看出，单独使用利福平治疗布鲁氏菌病的效果不如与另一种合适药物联合使用时的效果。
