Department of Dermatology, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan.
Eur J Dermatol. 2012 Sep-Oct;22(5):668-71. doi: 10.1684/ejd.2012.1824.
A variety of myositis-specific autoantibodies (MSAs) have been detected in patients with dermatomyositis (DM). We analyzed MSAs in 20 cases with DM. Eleven of the 20 cases were positive. Out of those 11 cases, 3 were positive for antibodies against aminoacyl-tRNA synthetase and 3 had antibodies to anti-melanoma differentiation-associated gene 5 detected using an immunoprecipitation assay and/or a specific enzyme-linked immunosorbent assay. One case had anti-NXP-2 antibodies and 4 cases had anti-transcriptional intermediary factor 1 (TIF1)-α/γ antibodies detected by immunoprecipitation and Western blotting. Two of those 4 cases had antibodies for both TIF1-α and TIF1-γ, and the 2 other cases had antibodies for TIF1-γ alone. We report the 2 cases with antibodies for TIF1-γ only, who were young-adult females without an internal malignancy or interstitial pneumonia. Those 2 cases had clinically amyopathic DM. Among DM patients with antibodies against TIF1 family proteins, there seems to be a subgroup of young-adult cases who have clinically amyopathic DM and show good prognosis without malignancy.
多种肌炎特异性自身抗体（MSAs）已在皮肌炎（DM）患者中被检测到。我们分析了 20 例 DM 患者的 MSAs。其中 11 例呈阳性。在这 11 例中，3 例为氨酰-tRNA 合成酶抗体阳性，3 例使用免疫沉淀法和/或特定酶联免疫吸附试验检测到抗黑色素瘤分化相关基因 5 抗体阳性。1 例为抗 NXP-2 抗体阳性，4 例为免疫沉淀和 Western blot 检测到抗转录中介因子 1（TIF1）-α/γ抗体阳性。这 4 例中有 2 例同时存在 TIF1-α 和 TIF1-γ 抗体，另外 2 例仅存在 TIF1-γ 抗体。我们报告了仅存在 TIF1-γ 抗体的 2 例患者，她们均为年轻成年女性，无内脏恶性肿瘤或间质性肺炎。这 2 例患者为临床无肌病性皮肌炎。在抗 TIF1 家族蛋白的 DM 患者中，似乎存在一组年轻成年患者，他们具有临床无肌病性皮肌炎，且无恶性肿瘤，预后良好。
