使用荧光蛋白缀合的金纳米猝灭剂对癌细胞中的蛋白水解途径进行级联成像。
Cascade imaging of proteolytic pathways in cancer cells using fluorescent protein-conjugated gold nanoquenchers.
机构信息
BioNanotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology, Major of Nanobiotechnology, University of Science and Technology, Gwahangno, Yuseong, Daejeon 305-806, Republic of Korea.
出版信息
Chem Commun (Camb). 2012 Nov 4;48(85):10547-9. doi: 10.1039/c2cc35687b.
PMID:22992541
Abstract
The real-time monitoring of the caspase cascade in cancer cells during apoptosis was performed using various caspase substrate-linked fluorescent proteins-conjugated gold nanoparticles as a new imaging probe.
摘要
采用各种连接半胱天冬酶底物的荧光蛋白标记的金纳米粒子作为新型成像探针，实时监测细胞凋亡过程中癌细胞中半胱天冬酶级联反应。
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