Owlia Parviz, Azimi Leila, Gholami Abbas, Asghari Babak, Lari Abdolaziz Rastegar
Antimicrobial Resistance Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Infez Med. 2012 Sep;20(3):182-7.
Acinetobacter baumannii is an important pathogen causing infections, especially in burnt patients. The aim of this study was to determine the prevalence of Extended Spectrum Beta-Lactamase (ESBL) and Metallo-Beta-Lactamase (MBL) in isolates of A. baumannii from burnt patients. One hundred-twenty-six A. baumannii strains were isolated from both male and female burnt patients admitted to Burnt Unit in Motahari hospital, Tehran. The susceptibility test was done by the disk combination technique. Disk test and disk diffusion methods were performed to confirm the production of ESBL and MBL in accordance with CLSI standard guidelines. Twenty-one percent of ceftazidime-resistance A. baumannii isolates were found to be ESBL producers. Thirty-nine percent of imipenem-resistant isolates produced MBL. Prolonged hospitalization of burnt patients made an important contribution to the incidence of resistant bacteria. The utility of an accurate surveillance for ESBL and MBL in A. baumannii isolated from burnt patients as an important step for successful antimicrobial treatment in the future.
鲍曼不动杆菌是一种引起感染的重要病原体，尤其是在烧伤患者中。本研究的目的是确定烧伤患者分离出的鲍曼不动杆菌中广谱β-内酰胺酶（ESBL）和金属β-内酰胺酶（MBL）的流行情况。从德黑兰莫塔哈里医院烧伤科收治的男性和女性烧伤患者中分离出126株鲍曼不动杆菌菌株。药敏试验采用纸片联合技术进行。按照CLSI标准指南进行纸片试验和纸片扩散法，以确认ESBL和MBL的产生。发现21%对头孢他啶耐药的鲍曼不动杆菌分离株为ESBL产生菌。39%对亚胺培南耐药的分离株产生MBL。烧伤患者的长期住院对耐药菌的发生率有重要影响。准确监测从烧伤患者中分离出的鲍曼不动杆菌中的ESBL和MBL，作为未来成功进行抗菌治疗的重要一步。
