Muzykewicz David A, Black Margaux E, Muse Victorine, Numis Adam L, Rajagopal Jayaraj, Thiele Elizabeth A, Sharma Amita
Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA.
J Comput Assist Tomogr. 2012 Sep-Oct;36(5):518-22. doi: 10.1097/RCT.0b013e318264e404.
To characterize pulmonary nodules in patients with tuberous sclerosis complex (TSC) using computed tomography.
We retrospectively reviewed chest computed tomographic images of 73 patients with TSC (22 males and 51 females; mean ± SD age, 31.5 ± 13.2 years; range, 13.8-63.5 years).
Multiple pulmonary nodules were identified in 42 (58%) of 73 patients (mean ± SD size, 6.6 ± 3.0 mm; range, 2-14 mm). Solid nodules were present in 11 (26%) of 42 patients, ground-glass nodules were present in 3 (7%) of 42 patients, and both solid and ground-glass nodules were present in 28 (67%) of 42 patients. The presence of multiple nodules was independent of sex and lymphangioleiomyomatosis. Follow-up images were available for 22 patients with multiple nodules (mean ± SD follow-up, 2.0 ± 1.1 years; range, 0.9-4.9 years), none of whom had change in nodule size or number.
Most men and women with TSC have multiple pulmonary nodules, which likely represent multifocal micronodular pneumocyte hyperplasia in the absence of known predisposing factors.
使用计算机断层扫描对结节性硬化症（TSC）患者的肺结节进行特征描述。
我们回顾性分析了73例TSC患者（22例男性和51例女性；平均±标准差年龄，31.5±13.2岁；范围，13.8 - 63.5岁）的胸部计算机断层扫描图像。
73例患者中有42例（58%）发现多个肺结节（平均±标准差大小，6.6±3.0 mm；范围，2 - 14 mm）。42例患者中有11例（26%）存在实性结节，42例患者中有3例（7%）存在磨玻璃结节，42例患者中有28例（67%）同时存在实性和磨玻璃结节。多个结节的存在与性别和淋巴管平滑肌瘤病无关。对22例有多个结节的患者进行了随访成像（平均±标准差随访时间，2.0±1.1年；范围，0.9 - 4.9年），这些患者中无一例结节大小或数量发生变化。
大多数TSC患者无论男女都有多个肺结节，在无已知易感因素的情况下这些结节可能代表多灶性微小结节性肺细胞增生。
