[β-肾上腺素受体在实现过量甲状腺激素的糖原分解和脂肪分解作用中的意义]
[Significance of beta-adrenoreception in realizing the glycogenolytic and lipolytic effects of excess thyroid hormones].
作者信息
Arslanov S N, Kriukova I V, Kandror V I
出版信息
Biull Eksp Biol Med. 1979 Dec;88(12):667-9.
PMID:229926
Abstract
In experiments on rats the chronic administration of beta-adrenoblocker obsidan (propranolol) in doses blocking the glycogenolytic and lipolytic effects of exogenous epinephrine does not prevent a decrease in the liver and heart glycogen level and an increase of free fatty acids (FFA) in the serum as well as of lipolytic activity of adipose tissue in vitro, which are produced by high doses of thyroxine.
摘要
在对大鼠的实验中，长期给予能阻断外源性肾上腺素糖原分解和脂肪分解作用剂量的β-肾上腺素能阻滞剂奥昔丹（普萘洛尔），并不能防止高剂量甲状腺素所引起的肝脏和心脏糖原水平降低、血清中游离脂肪酸（FFA）增加以及体外脂肪组织脂肪分解活性增强。
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