Witmanowski H, Torlińska T, Paluszak J
Acta Physiol Pol. 1985 Jul-Aug;36(4):270-5.
The effect of 2-deoxy-D-glucose on lipolytic processes in the blood and adipose tissue was studied. Rats treated with this antimetabolite showed a significant increase in serum glucose, FFA and glycerol level, as well as in the lipid mobilizing activity. On the other hand, the lipolytic activity of rat serum decreased when compared to control group. From these results it may be concluded that during hypothermia induced by administration of 2-deoxy-D-glucose intracellular, but not intravascular, lipolysis is enhanced.
研究了2-脱氧-D-葡萄糖对血液和脂肪组织中脂解过程的影响。用这种抗代谢物处理的大鼠血清葡萄糖、游离脂肪酸和甘油水平以及脂质动员活性显著增加。另一方面，与对照组相比，大鼠血清的脂解活性降低。从这些结果可以得出结论，在由2-脱氧-D-葡萄糖给药诱导的体温过低期间，细胞内而非血管内的脂解作用增强。
