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Alcohol inhibits alveolar fluid clearance through the epithelial sodium channel via the A2 adenosine receptor in acute lung injury.酒精通过急性肺损伤中的 A2 腺苷受体抑制肺泡液体清除通过上皮钠离子通道。
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Cytokine-Ion Channel Interactions in Pulmonary Inflammation.肺部炎症中的细胞因子-离子通道相互作用
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Regulation of Lung Epithelial Sodium Channels by Cytokines and Chemokines.细胞因子和趋化因子对肺上皮钠通道的调节
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Fulvene-5 inhibition of Nadph oxidases attenuates activation of epithelial sodium channels in A6 distal nephron cells.富勒烯-5 抑制 NADPH 氧化酶可减轻 A6 远曲肾小管细胞上皮钠通道的激活。
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Ethanol stimulates epithelial sodium channels by elevating reactive oxygen species.乙醇通过提高活性氧来刺激上皮钠离子通道。
Am J Physiol Cell Physiol. 2012 Dec 1;303(11):C1129-38. doi: 10.1152/ajpcell.00139.2012. Epub 2012 Aug 15.

本文引用的文献

1
Ethanol stimulates epithelial sodium channels by elevating reactive oxygen species.乙醇通过提高活性氧来刺激上皮钠离子通道。
Am J Physiol Cell Physiol. 2012 Dec 1;303(11):C1129-38. doi: 10.1152/ajpcell.00139.2012. Epub 2012 Aug 15.
2
Angiotensin II stimulates epithelial sodium channels in the cortical collecting duct of the rat kidney.血管紧张素 II 刺激大鼠肾脏皮质集合管中的上皮钠通道。
Am J Physiol Renal Physiol. 2012 Mar 15;302(6):F679-87. doi: 10.1152/ajprenal.00368.2011. Epub 2011 Dec 14.
3
Nadph oxidase regulates alveolar epithelial sodium channel activity and lung fluid balance in vivo via O⁻₂ signaling.NADPH 氧化酶通过 O₂⁻信号调节体内肺泡上皮钠通道活性和肺液平衡。
Am J Physiol Lung Cell Mol Physiol. 2012 Feb 15;302(4):L410-9. doi: 10.1152/ajplung.00260.2011. Epub 2011 Dec 9.
4
Hydrogen peroxide stimulates the epithelial sodium channel through a phosphatidylinositide 3-kinase-dependent pathway.过氧化氢通过磷脂酰肌醇 3-激酶依赖途径刺激上皮钠通道。
J Biol Chem. 2011 Sep 16;286(37):32444-53. doi: 10.1074/jbc.M111.254102. Epub 2011 Jul 27.
5
Structural basis for alcohol modulation of a pentameric ligand-gated ion channel.酒精调节五聚体配体门控离子通道的结构基础。
Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):12149-54. doi: 10.1073/pnas.1104480108. Epub 2011 Jul 5.
6
Rac1-mediated NADPH oxidase release of O2- regulates epithelial sodium channel activity in the alveolar epithelium.Rac1 介导的 NADPH 氧化酶释放的 O2- 调节肺泡上皮细胞中的上皮钠通道活性。
Am J Physiol Lung Cell Mol Physiol. 2010 Apr;298(4):L509-20. doi: 10.1152/ajplung.00230.2009. Epub 2010 Jan 22.
7
Down-regulating destruction: phosphorylation regulates the E3 ubiquitin ligase Nedd4-2.下调破坏作用:磷酸化调节E3泛素连接酶Nedd4-2。
Sci Signal. 2009 Jul 14;2(79):pe41. doi: 10.1126/scisignal.279pe41.
8
Influenza virus M2 protein inhibits epithelial sodium channels by increasing reactive oxygen species.流感病毒M2蛋白通过增加活性氧来抑制上皮钠通道。
FASEB J. 2009 Nov;23(11):3829-42. doi: 10.1096/fj.09-135590. Epub 2009 Jul 13.
9
Aldosterone-induced increases in superoxide production counters nitric oxide inhibition of epithelial Na channel activity in A6 distal nephron cells.醛固酮诱导的超氧化物生成增加抵消了一氧化氮对A6远端肾单位细胞上皮钠通道活性的抑制作用。
Am J Physiol Renal Physiol. 2007 Nov;293(5):F1666-77. doi: 10.1152/ajprenal.00444.2006. Epub 2007 Sep 5.
10
Reactive species mediate inhibition of alveolar type II sodium transport during mycoplasma infection.活性物质在支原体感染期间介导肺泡II型上皮细胞钠转运的抑制。
Am J Respir Crit Care Med. 2006 Feb 1;173(3):334-44. doi: 10.1164/rccm.200501-155OC. Epub 2005 Oct 27.

Intoxicated Na(+) channels. Focus on "ethanol stimulates epithelial sodium channels by elevating reactive oxygen species".

作者信息

Snyder Peter M

出版信息

Am J Physiol Cell Physiol. 2012 Dec 1;303(11):C1125-6. doi: 10.1152/ajpcell.00301.2012. Epub 2012 Sep 19.

DOI:10.1152/ajpcell.00301.2012
PMID:22992679
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3530772/
Abstract
摘要