Cruz M E, Morán J L, Jaramillo L P, Domínguez R
Laboratory of Biology of Reproduction, Escuela Nacional de Estudios Profesionales Zaragoza, UNAM, D.F., Mexico.
J Endocrinol. 1990 Jan;124(1):37-41. doi: 10.1677/joe.0.1240037.
The effects were analysed of a unilateral lesion in the anterior or medial hypothalamus made on the day of oestrus on right or left hemicastrated rats. On the day of oestrus after two consecutive oestrous cycles of the same length, the ovulation rate in rats with lesions in the anterior left hypothalamus was lower than in control hemicastrated animals (5/16 vs 18/20; P less than 0.01), and normal in those rats with lesions in the right side (14/18). None of the animals with lesions in the left side of the anterior hypothalamus and with the left ovary in situ ovulated (0/7), but 5/9 with the right ovary in situ did ovulate (P less than 0.05). Lesions on either side of the medial hypothalamus did not modify ovulation rate. Compensatory ovulation was reduced in those animals with lesions in the right anterior hypothalamus and with the right ovary in situ. Lesions in either side of the medial hypothalamus reduced compensatory ovulation. Lesions in the right side of the anterior and medial hypothalamus increased compensatory ovarian hypertrophy in the left ovary and decreased it in the right ovary. Lesions in the left side of the anterior hypothalamus increased compensatory ovarian hypertrophy in the left ovary only, whereas lesions in the left side of the medial hypothalamus reduced compensatory ovarian hypertrophy in the right ovary. The results suggest that the information arising in each side of the anterior and medial hypothalamus plays different roles in the ipsi-and contralateral ovary, when either the left or the right ovary is absent.
分析了在发情日对右侧或左侧半阉割大鼠的下丘脑前部或内侧进行单侧损伤的影响。在经历两个长度相同的连续发情周期后的发情日，左侧下丘脑前部有损伤的大鼠的排卵率低于对照半阉割动物（5/16对18/20；P<0.01），而右侧有损伤的大鼠排卵率正常（14/18）。左侧下丘脑前部有损伤且左侧卵巢原位的动物均未排卵（0/7），但右侧卵巢原位的9只中有5只排卵（P<0.05）。下丘脑内侧两侧的损伤均未改变排卵率。右侧下丘脑前部有损伤且右侧卵巢原位的动物的代偿性排卵减少。下丘脑内侧两侧的损伤均减少了代偿性排卵。下丘脑前部和内侧右侧的损伤增加了左侧卵巢的代偿性卵巢肥大，而右侧卵巢的代偿性卵巢肥大减少。左侧下丘脑前部的损伤仅增加了左侧卵巢的代偿性卵巢肥大，而左侧下丘脑内侧的损伤减少了右侧卵巢的代偿性卵巢肥大。结果表明，当下丘脑前部和内侧两侧的信息在同侧和对侧卵巢中发挥不同作用时，左侧或右侧卵巢缺失。
