Sanchez M A, Dominguez R
Biology of Reproduction Research Unit, FES Zaragoza UNAM, México DF.
Brain Res Bull. 1995;38(4):313-7. doi: 10.1016/0361-9230(95)00094-u.
The possible existence of asymmetry in the control of ovulation by the medial amygdala was explored. Unilateral lesions of the medial amygdala were performed on each day of the estrous cycle. The estral index diminished in almost all animals with a lesion in the right side of medial amygdala. Lesions of the right medial amygdala, when performed on diestrus-1, resulted in a significant decrease in the number of rats ovulating compared to controls (4/8 vs. 8/8, p < 0.05). In ovulating animals a significant reduction in the number of ova shed by the left ovary was found (2.2 +/- 0.8 vs. 6.3 +/- 0.8, p < 0.05). Lesions of the stria terminalis performed on diestrus-1 did not affect ovulation. In a second experiment, administration of GnRH did not restore ovulation in rats with lesions of the right medial amygdala. However, sequential injections of PMSG-hCG did result in ovulation by all members of a group of lesioned animals. In this last condition a significant decrease in the number of ova shed by the right ovary was found compared to animals in the lesion-only condition (1.5 +/- 0.5 vs. 6.0 +/- 1.5, p < 0.05). These data suggest that control of ovulation by the medial amygdala is asymmetric and varies during the estrous cycle.
研究了内侧杏仁核在排卵控制中可能存在的不对称性。在发情周期的每一天对内侧杏仁核进行单侧损伤。几乎所有右侧内侧杏仁核有损伤的动物，其发情指数均降低。在动情间期-1对右侧内侧杏仁核进行损伤时，与对照组相比，排卵大鼠的数量显著减少（4/8 对 8/8，p<0.05）。在排卵动物中，发现左侧卵巢排出的卵子数量显著减少（2.2±0.8 对 6.3±0.8，p<0.05）。在动情间期-1对终纹床核进行损伤并不影响排卵。在第二个实验中，给予促性腺激素释放激素（GnRH）并不能恢复右侧内侧杏仁核有损伤的大鼠的排卵。然而，连续注射孕马血清促性腺激素（PMSG）-人绒毛膜促性腺激素（hCG）确实能使一组有损伤的动物全部排卵。在最后这种情况下，与仅损伤的动物相比，发现右侧卵巢排出的卵子数量显著减少（1.5±0.5 对 6.0±1.5，p<0.05）。这些数据表明，内侧杏仁核对排卵的控制是不对称的，并且在发情周期中有所变化。
