School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 500-712, Republic of Korea.
Oncol Rep. 2012 Dec;28(6):2217-20. doi: 10.3892/or.2012.2043. Epub 2012 Sep 18.
RON is a proto-oncogene that induces cell dissociation, migration and matrix invasion. RON∆160, a splicing variant of RON, is a natural splicing product in colon cancers that is produced through skipping of exons 5 and 6 in alternative splicing process. RON∆160 promotes cellular transformation in vitro and tumor formation in vivo. We present, here, two novel splicing variants of RON in the partial splicing events that involve exons 5 and 6. The common facts of these two novel splicing variants are that exons 4-7 are included. In addition, intron 4 is spliced whereas intron 5 is included in both variants. The difference of these two isoforms is the inclusion or skipping of intron 6. In one variant intron 6 is included, but intron 6 is skipped in another variant. These two variants should be truncated but these proteins have not yet been detected.
RON 是一种原癌基因，可诱导细胞分离、迁移和基质侵袭。RON∆160 是 RON 的剪接变体，是结肠癌中的一种天然剪接产物，通过选择性剪接过程中外显子 5 和 6 的跳过产生。RON∆160 促进体外细胞转化和体内肿瘤形成。在这里，我们提出了 RON 在涉及外显子 5 和 6 的部分剪接事件中的两个新的剪接变体。这两个新剪接变体的共同特征是包含外显子 4-7。此外，两个变体都剪接了内含子 4，而内含子 5 则都包含在内。这两种异构体的区别在于内含子 6 的包含或跳过。在一个变体中外显子 6 包含在内，但在另一个变体中外显子 6 被跳过。这两种变体应该是截断的，但这些蛋白质尚未被检测到。
