Glik D C, Steadman M S, Michels P J, Mallin R
Department of Health Promotion and Family Medicine, University of South Carolina School of Medicine, Columbia 29203.
J Fam Pract. 1990 Feb;30(2):143-9; discussion 150-2.
A sample of family practice patients with essential hypertension (N = 106) who were predominantly elderly, black, and disadvantaged were studied to determine psychosocial and physiological side effects from antihypertensive therapy regimens. Patients were assigned randomly to one of four monotherapy treatment groups: Hydrochlorothiazide-triamterene, metoprolol, captopril, and methyldopa. These medications have been reported to have contrasting effects on quality of life. Measurements of quality of life, physical symptoms, and depression taken at baseline and during therapy revealed few significant changes in these indicators. Changes in mean levels of diastolic and systolic hypertension over time were clinically and statistically significant. Findings raise issues regarding medication effectiveness and cost given the disadvantaged population studied.
对106名原发性高血压家庭医疗患者进行了研究，这些患者主要为老年人、黑人且处于社会经济劣势地位，旨在确定抗高血压治疗方案的心理社会和生理副作用。患者被随机分配到四个单药治疗组之一：氢氯噻嗪-氨苯蝶啶、美托洛尔、卡托普利和甲基多巴。据报道，这些药物对生活质量有不同影响。在基线和治疗期间对生活质量、身体症状和抑郁进行的测量显示，这些指标几乎没有显著变化。随着时间推移，舒张压和收缩压高血压平均水平的变化在临床和统计学上具有显著性。鉴于所研究的弱势群体，研究结果引发了有关药物疗效和成本的问题。
