卡波氏肉瘤相关疱疹病毒 ORF57 不是真正的输出因子。
Kaposi's sarcoma-associated herpesvirus ORF57 is not a bona fide export factor.
机构信息
Human Retrovirus Pathogenesis Section, Vaccine Branch, Center for Cancer Research, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.
出版信息
J Virol. 2012 Dec;86(23):13089-94. doi: 10.1128/JVI.00606-12. Epub 2012 Sep 19.
Abstract
Kaposi's sarcoma-associated herpesvirus (KSHV [human herpesvirus 8; HHV-8]) open reading frame 57 (ORF57) is a viral early protein participating in posttranscriptional regulatory events, such as splicing, RNA stabilization, and protein expression. Recent data suggest that ORF57 recruits the transcription and export (TREX) complex to viral RNA and exports these transcripts to the cytoplasm. In this study, we show that although ORF57 promotes expression of a selection of KSHV viral intronless RNAs, it is not a bona fide export factor.
摘要
卡波济肉瘤相关疱疹病毒（KSHV [人类疱疹病毒 8；HHV-8]）开放阅读框 57（ORF57）是一种参与转录后调控事件的病毒早期蛋白，如剪接、RNA 稳定和蛋白质表达。最近的数据表明，ORF57 将转录和输出（TREX）复合物募集到病毒 RNA 上，并将这些转录物输出到细胞质中。在这项研究中，我们表明，尽管 ORF57 促进了一系列 KSHV 无内含子 RNA 的表达，但它不是一个真正的输出因子。
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