Moore Melissa J, Proudfoot Nick J
Howard Hughes Medical Institute, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA.
Cell. 2009 Feb 20;136(4):688-700. doi: 10.1016/j.cell.2009.02.001.
The pathway from gene activation in the nucleus to mRNA translation and decay at specific locations in the cytoplasm is both streamlined and highly interconnected. This review discusses how pre-mRNA processing, including 5' cap addition, splicing, and polyadenylation, contributes to both the efficiency and fidelity of gene expression. The connections of pre-mRNA processing to upstream events in transcription and downstream events, including translation and mRNA decay, are elaborate, extensive, and remarkably interwoven.
从细胞核中的基因激活到细胞质中特定位置的mRNA翻译及降解的过程既精简又高度相互关联。本综述讨论了前体mRNA加工，包括5' 端加帽、剪接和聚腺苷酸化，如何对基因表达的效率和保真度产生影响。前体mRNA加工与转录中的上游事件以及包括翻译和mRNA降解在内的下游事件之间的联系复杂、广泛且交织紧密。
