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本文引用的文献

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Missing mec.mec缺失
Clin Infect Dis. 2011 Nov;53(10):iii-iv. doi: 10.1093/cid/cir648.
2
Meticillin-resistant Staphylococcus aureus with a novel mecA homologue in human and bovine populations in the UK and Denmark: a descriptive study.英国和丹麦人群及牛群中新型 mecA 同源物的耐甲氧西林金黄色葡萄球菌：描述性研究。
Lancet Infect Dis. 2011 Aug;11(8):595-603. doi: 10.1016/S1473-3099(11)70126-8.
3
Detection of staphylococcal cassette chromosome mec type XI carrying highly divergent mecA, mecI, mecR1, blaZ, and ccr genes in human clinical isolates of clonal complex 130 methicillin-resistant Staphylococcus aureus.检测到携带高度变异的 mecA、mecI、mecR1、blaZ 和 ccr 基因的葡萄球菌盒式染色体 mec 类型 XI，这些基因存在于克隆复合体 130 型耐甲氧西林金黄色葡萄球菌的人类临床分离株中。
Antimicrob Agents Chemother. 2011 Aug;55(8):3765-73. doi: 10.1128/AAC.00187-11. Epub 2011 Jun 2.
4
A field guide to pandemic, epidemic and sporadic clones of methicillin-resistant Staphylococcus aureus.耐甲氧西林金黄色葡萄球菌大流行、流行和散发克隆的实地指南。
PLoS One. 2011 Apr 6;6(4):e17936. doi: 10.1371/journal.pone.0017936.
5
Recombination between ccrC genes in a type V (5C2&5) staphylococcal cassette chromosome mec (SCCmec) of Staphylococcus aureus ST398 leads to conversion from methicillin resistance to methicillin susceptibility in vivo.金黄色葡萄球菌 ST398 型 V 组（5C2&5）葡萄球菌盒式染色体 mec（SCCmec）中 ccrC 基因的重组导致体内由耐甲氧西林转换为甲氧西林敏感。
Antimicrob Agents Chemother. 2010 Feb;54(2):783-91. doi: 10.1128/AAC.00696-09. Epub 2009 Dec 7.
6
Evaluation of the BD GeneOhm StaphSR assay for detection of methicillin-resistant and methicillin-susceptible Staphylococcus aureus isolates from spiked positive blood culture bottles.评估BD GeneOhm StaphSR检测法用于从加标阳性血培养瓶中检测耐甲氧西林和甲氧西林敏感金黄色葡萄球菌分离株的性能。
J Clin Microbiol. 2009 Jun;47(6):1689-94. doi: 10.1128/JCM.02179-08. Epub 2009 Apr 15.
7
Genomic analysis of an emerging multiresistant Staphylococcus aureus strain rapidly spreading in cystic fibrosis patients revealed the presence of an antibiotic inducible bacteriophage.对一种在囊性纤维化患者中迅速传播的新型多重耐药金黄色葡萄球菌菌株进行的基因组分析显示，存在一种抗生素诱导噬菌体。
Biol Direct. 2009 Jan 13;4:1. doi: 10.1186/1745-6150-4-1.
8
In vitro and in vivo evaluations of oxacillin efficiency against mecA-positive oxacillin-susceptible Staphylococcus aureus.针对mecA基因阳性但对苯唑西林敏感的金黄色葡萄球菌的苯唑西林疗效的体外和体内评估。
Antimicrob Agents Chemother. 2008 Nov;52(11):3905-8. doi: 10.1128/AAC.00653-08. Epub 2008 Aug 11.
9
Assignment of Staphylococcus aureus isolates to clonal complexes based on microarray analysis and pattern recognition.基于微阵列分析和模式识别将金黄色葡萄球菌分离株归类到克隆复合体
FEMS Immunol Med Microbiol. 2008 Jul;53(2):237-51. doi: 10.1111/j.1574-695X.2008.00426.x. Epub 2008 May 27.
10
DNA microarray-based genotyping of methicillin-resistant Staphylococcus aureus strains from Eastern Saxony.基于DNA微阵列技术对来自萨克森州东部的耐甲氧西林金黄色葡萄球菌菌株进行基因分型。
Clin Microbiol Infect. 2008 Jun;14(6):534-45. doi: 10.1111/j.1469-0691.2008.01986.x. Epub 2008 Mar 27.

基因耐药性检测带来新的治疗挑战：两例耐甲氧西林金黄色葡萄球菌但对苯唑西林敏感。

Genotypic resistance testing creates new treatment challenges: two cases of oxacillin-susceptible methicillin-resistant Staphylococcus aureus.

机构信息

Division of Infectious Diseases, Oregon Health and Science University, Portland, Oregon, USA.

出版信息

J Clin Microbiol. 2012 Dec;50(12):4151-3. doi: 10.1128/JCM.01564-12. Epub 2012 Sep 19.

DOI:10.1128/JCM.01564-12
PMID:22993184
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3502964/
Abstract

Oxacillin-susceptible, mecA-positive Staphylococcus aureus isolates create a treatment challenge for the clinician. In this article, we describe two cases of bacteremia from isolates that carried the mecA gene but were susceptible to oxacillin (oxacillin-susceptible methicillin-resistant S. aureus [OS-MRSA]). DNA microarray analysis was used to characterize these isolates as a mecA-positive, clonal complex 5, pediatric strain and a mecA-positive, clonal complex 8, USA300 strain.

摘要

耐苯唑西林、mecA 阳性金黄色葡萄球菌分离株给临床医生带来了治疗挑战。在本文中，我们描述了两例由携带 mecA 基因但对苯唑西林敏感（耐苯唑西林、耐甲氧西林金黄色葡萄球菌 [OS-MRSA]）的分离株引起的菌血症。DNA 微阵列分析将这些分离株鉴定为 mecA 阳性、克隆复合体 5、儿科株和 mecA 阳性、克隆复合体 8、USA300 株。