检测和定量分析良、恶性腮腺病变中的人乳头瘤病毒。
Detection and quantification of human papillomavirus in benign and malignant parotid lesions.
机构信息
Laboratory of Anatomy, Faculty of Medicine and Pharmacy, University of Mons, Mons, Belgium.
出版信息
Anticancer Res. 2012 Sep;32(9):3929-32.
BACKGROUND/AIM: Human papillomavirus (HPV) is implicated in head and neck squamous cell carcinomas. However, the causal role of HPV in carcinomas of the parotid gland remains uncertain and less documented. This study aimed to determine the potential implication of HPV in the development of benign and malignant lesions of the parotid gland.
MATERIALS AND METHODS
Paraffin-embedded biopsies were obtained from 40 patients with benign parotid gland tumors and from 39 patients with parotid gland carcinomas. The 79 samples were evaluated for the presence of HPV DNA using both GP5+/GP6+ consensus Polymerase Chain Reaction (PCR) and type-specific E6/E7 PCR to detect 18 HPV types.
RESULTS
Our results showed a low prevalence of HPV, with only three HPV-positive cases among the 40 benign tumors and one infected carcinoma in the malignant population.
CONCLUSION
No association between the presence of HPV DNA and the development of parotid gland tumors was found in our study.
背景/目的：人乳头瘤病毒（HPV）与头颈部鳞状细胞癌有关。然而，HPV 在腮腺癌中的因果作用仍不确定，相关文献也较少。本研究旨在确定 HPV 是否可能参与腮腺良、恶性病变的发生。
材料和方法
从 40 例腮腺良性肿瘤患者和 39 例腮腺癌患者的石蜡包埋活检组织中获取标本。使用 GP5+/GP6+ 通用聚合酶链反应（PCR）和针对 18 种 HPV 类型的 E6/E7 型特异性 PCR 检测 79 例样本中 HPV DNA 的存在。
结果
我们的结果显示 HPV 阳性率较低，在 40 例良性肿瘤中仅有 3 例 HPV 阳性，在恶性肿瘤中仅 1 例癌组织中存在 HPV 感染。
结论
在本研究中，未发现 HPV DNA 的存在与腮腺肿瘤的发生之间存在关联。
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