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模拟白色念珠菌β-(1->2)连接细胞壁甘露聚糖的含合成甘露糖结构的免疫刺激活性评估。

Evaluation of immunostimulatory activities of synthetic mannose-containing structures mimicking the β-(1->2)-linked cell wall mannans of Candida albicans.

作者信息

Ranta Kaarina, Nieminen Kaisa, Ekholm Filip S, Poláková Moniká, Roslund Mattias U, Saloranta Tiina, Leino Reko, Savolainen Johannes

机构信息

Department of Pulmonary Diseases and Clinical Allergology, University of Turku, Turku, Finland.

出版信息

Clin Vaccine Immunol. 2012 Nov;19(11):1889-93. doi: 10.1128/CVI.00298-12. Epub 2012 Sep 19.

DOI:10.1128/CVI.00298-12
PMID:22993407
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3491550/
Abstract

Immunostimulatory properties of synthetic structures mimicking the β-(1→2)-linked mannans of Candida albicans were evaluated in vitro. Contrary to earlier observations, tumor necrosis factor (TNF) production was not detected after stimulation with mannotetraose in mouse macrophages. Divalent disaccharide 1,4-bis(α-D-mannopyranosyloxy)butane induced TNF and some molecules induced low levels of gamma interferon (IFN-γ) in human peripheral blood mononuclear cells (PBMC).

摘要

在体外评估了模拟白色念珠菌β-(1→2)-连接甘露聚糖的合成结构的免疫刺激特性。与早期观察结果相反，在小鼠巨噬细胞中用甘露四糖刺激后未检测到肿瘤坏死因子（TNF）的产生。二价二糖1,4-双(α-D-甘露吡喃糖氧基)丁烷在人外周血单核细胞（PBMC）中诱导TNF产生，一些分子诱导低水平的γ干扰素（IFN-γ）。

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1
Evaluation of immunostimulatory activities of synthetic mannose-containing structures mimicking the β-(1->2)-linked cell wall mannans of Candida albicans.模拟白色念珠菌β-(1->2)连接细胞壁甘露聚糖的含合成甘露糖结构的免疫刺激活性评估。
Clin Vaccine Immunol. 2012 Nov;19(11):1889-93. doi: 10.1128/CVI.00298-12. Epub 2012 Sep 19.
2
The Candida albicans phospholipomannan induces in vitro production of tumour necrosis factor-alpha from human and murine macrophages.白色念珠菌磷脂甘露聚糖可在体外诱导人和小鼠巨噬细胞产生肿瘤坏死因子-α。
Immunology. 1994 Oct;83(2):268-73.
3
The mannan of Candida albicans lacking β-1,2-linked oligomannosides increases the production of inflammatory cytokines by dendritic cells.缺乏β-1,2-连接寡甘露糖的白色念珠菌甘露聚糖可增加树突状细胞炎性细胞因子的产生。
Med Mycol. 2013 May;51(4):385-95. doi: 10.3109/13693786.2012.733892. Epub 2012 Oct 29.
4
In vitro production of tumor necrosis factor by murine splenic macrophages stimulated with mannoprotein constituents of Candida albicans cell wall.白色念珠菌细胞壁甘露糖蛋白成分刺激小鼠脾巨噬细胞体外产生肿瘤坏死因子
Cell Immunol. 1991 Apr 15;134(1):65-76. doi: 10.1016/0008-8749(91)90331-5.
5
Generation and characterization of cytotoxic activity against tumor cell lines in human peripheral blood mononuclear cells stimulated "in vitro" by a glucomannan-protein preparation of Candida albicans.由白色念珠菌葡甘露聚糖-蛋白质制剂“体外”刺激的人外周血单个核细胞中针对肿瘤细胞系的细胞毒性活性的产生与特性分析
J Biol Regul Homeost Agents. 1987 Apr-Jun;1(2):59-68.
6
Immune sensing of Candida albicans requires cooperative recognition of mannans and glucans by lectin and Toll-like receptors.白色念珠菌的免疫感知需要凝集素和Toll样受体对甘露聚糖和葡聚糖的协同识别。
J Clin Invest. 2006 Jun;116(6):1642-50. doi: 10.1172/JCI27114. Epub 2006 May 18.
7
[Demonstration of β-1,2 mannan structures expressed on the cell wall of Candida albicans yeast form but not on the hyphal form by using monoclonal antibodies].[利用单克隆抗体证明白色念珠菌酵母形式而非菌丝形式的细胞壁上表达的β-1,2甘露聚糖结构]
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Existence of branched side chains in the cell wall mannan of pathogenic yeast, Candida albicans. Structure-antigenicity relationship between the cell wall mannans of Candida albicans and Candida parapsilosis.致病性酵母白色念珠菌细胞壁甘露聚糖中支链侧链的存在。白色念珠菌与近平滑念珠菌细胞壁甘露聚糖之间的结构-抗原性关系。
J Biol Chem. 1995 Jan 20;270(3):1113-22. doi: 10.1074/jbc.270.3.1113.
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Mannoprotein-induced anti-U937 cell cytotoxicity in peripheral blood mononuclear cells from uninfected or HIV-infected subjects: role of interferon-gamma and tumor necrosis factor-alpha.甘露糖蛋白诱导未感染或HIV感染受试者外周血单个核细胞中抗U937细胞的细胞毒性：γ干扰素和肿瘤坏死因子-α的作用
Cell Immunol. 1993 Dec;152(2):530-43. doi: 10.1006/cimm.1993.1310.
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Th17 cells bounce off the fungal wall.辅助性T细胞17（Th17）细胞从真菌壁反弹。
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Polyvalent Interactions in Biological Systems: Implications for Design and Use of Multivalent Ligands and Inhibitors.生物系统中的多价相互作用：对多价配体和抑制剂设计与应用的启示
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Specific recognition of Candida albicans by macrophages requires galectin-3 to discriminate Saccharomyces cerevisiae and needs association with TLR2 for signaling.巨噬细胞对白色念珠菌的特异性识别需要半乳糖凝集素-3来区分酿酒酵母，并且需要与Toll样受体2（TLR2）结合以进行信号传导。
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Differential infection of mononuclear phagocytes by Francisella tularensis: role of the macrophage mannose receptor.土拉弗朗西斯菌对单核吞噬细胞的差异性感染：巨噬细胞甘露糖受体的作用
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Direct chemical synthesis of the beta-D-mannans: the beta-(1-->2) and beta-(1-->4) series.β-D-甘露聚糖的直接化学合成：β-(1→2)和β-(1→4)系列
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Candida albicans cell wall glycans, host receptors and responses: elements for a decisive crosstalk.白色念珠菌细胞壁聚糖、宿主受体与反应：决定性相互作用的要素
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Surface glycans of Candida albicans and other pathogenic fungi: physiological roles, clinical uses, and experimental challenges.白色念珠菌及其他致病真菌的表面聚糖：生理作用、临床应用及实验挑战
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