模拟白色念珠菌β-(1->2)连接细胞壁甘露聚糖的含合成甘露糖结构的免疫刺激活性评估。
Evaluation of immunostimulatory activities of synthetic mannose-containing structures mimicking the β-(1->2)-linked cell wall mannans of Candida albicans.
作者信息
Ranta Kaarina, Nieminen Kaisa, Ekholm Filip S, Poláková Moniká, Roslund Mattias U, Saloranta Tiina, Leino Reko, Savolainen Johannes
机构信息
Department of Pulmonary Diseases and Clinical Allergology, University of Turku, Turku, Finland.
出版信息
Clin Vaccine Immunol. 2012 Nov;19(11):1889-93. doi: 10.1128/CVI.00298-12. Epub 2012 Sep 19.
Abstract
Immunostimulatory properties of synthetic structures mimicking the β-(1→2)-linked mannans of Candida albicans were evaluated in vitro. Contrary to earlier observations, tumor necrosis factor (TNF) production was not detected after stimulation with mannotetraose in mouse macrophages. Divalent disaccharide 1,4-bis(α-D-mannopyranosyloxy)butane induced TNF and some molecules induced low levels of gamma interferon (IFN-γ) in human peripheral blood mononuclear cells (PBMC).
摘要
在体外评估了模拟白色念珠菌β-(1→2)-连接甘露聚糖的合成结构的免疫刺激特性。与早期观察结果相反，在小鼠巨噬细胞中用甘露四糖刺激后未检测到肿瘤坏死因子（TNF）的产生。二价二糖1,4-双(α-D-甘露吡喃糖氧基)丁烷在人外周血单核细胞（PBMC）中诱导TNF产生，一些分子诱导低水平的γ干扰素（IFN-γ）。
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