Cox-2和PPARγ信号通路在抗癌治疗中的应用。
The use of Cox-2 and PPARγ signaling in anti-cancer therapies.
作者信息
Knopfová Lucia, Smarda Jan
机构信息
Department of Experimental Biology, Faculty of Science, Masaryk University, 611 37 Brno, Czech Republic.
出版信息
Exp Ther Med. 2010 Mar;1(2):257-264. doi: 10.3892/etm_00000040. Epub 2010 Mar 1.
Abstract
Increased production of the pro-inflammatory enzyme cyclooxygenase-2 (Cox-2) and altered expression and activity of peroxisome proliferator-activated receptor γ (PPARγ) have been observed in many malignancies. Both the PPARγ ligands and the Cox-2 inhibitors possess anti-inflammatory and anti-neoplastic effects in vitro and have been assessed for their therapeutic potential in several pre-clinical and clinical studies. Recently, multiple interactions between PPARγ and Cox-2 signaling pathways have been revealed. Understanding of the cross-talk between PPARγ and Cox-2 might provide important novel strategies for the effective treatment and/or prevention of cancer. This article summarizes recent achievements involving the functional interactions between the PPARγ and Cox-2 signaling pathways and discusses the implications of such interplay for clinical use.
摘要
在许多恶性肿瘤中都观察到促炎酶环氧化酶-2（Cox-2）的产量增加以及过氧化物酶体增殖物激活受体γ（PPARγ）的表达和活性改变。PPARγ配体和Cox-2抑制剂在体外均具有抗炎和抗肿瘤作用，并且已在多项临床前和临床研究中评估了它们的治疗潜力。最近，PPARγ和Cox-2信号通路之间的多种相互作用已被揭示。了解PPARγ和Cox-2之间的相互作用可能为有效治疗和/或预防癌症提供重要的新策略。本文总结了PPARγ和Cox-2信号通路之间功能相互作用的最新成果，并讨论了这种相互作用在临床应用中的意义。
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