Yoshikawa Nobuhiko, Inomata Taisuke, Shinbo Taiju, Takahashi Masatsugu, Uesugi Yasuo, Narumi Yoshihumi
Department of Radiology, Osaka Medical College, Osaka 569-8686, Japan.
Exp Ther Med. 2010 May;1(3):453-455. doi: 10.3892/etm_00000070. Epub 2010 May 1.
The present study reports on a case of extra-nodal natural killer/T cell lymphoma, nasal-type (ENKL), stage IIEA, in a 50-year-old woman who presented with a white tumor on a refractory ulcer on the gum. Concurrent chemoradiotherapy was administered, and effected a partial response. However, tumor recurrence was observed 5 months after the final diagnosis, and the patient succumbed 1 month after recurrence. Although a definitive treatment for ENKL has yet to be established due to its rarity, radiation therapy (RT) is crucial to therapy, as ENKL is very sensitive to RT. However, treatment with radiation levels above 50 Gy with an extended RT field are required for a favorable outcome. The development of novel chemotherapy regimens may therefore be useful. Additionally, autologous or allogenic hematopoietic stem-cell transplantation may prove to be a promising approach.
本研究报告了一例50岁女性的结外自然杀伤/T细胞淋巴瘤，鼻型（ENKL），IIEA期，该患者牙龈难治性溃疡处出现白色肿物。给予同步放化疗，取得部分缓解。然而，最终诊断5个月后观察到肿瘤复发，患者在复发1个月后死亡。尽管由于ENKL罕见，其确切治疗方法尚未确立，但放射治疗（RT）对治疗至关重要，因为ENKL对RT非常敏感。然而，为取得良好疗效，需要采用50 Gy以上的放射剂量并扩大放疗野进行治疗。因此，开发新的化疗方案可能会有所帮助。此外，自体或异基因造血干细胞移植可能是一种有前景的方法。
