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一名患有格雷夫斯病的女性的早发性乳腺癌。

Early-onset breast cancer in a woman with Graves' disease.

作者信息

Siegler James E, Li Xinying, Jones Steven D, Kandil Emad

机构信息

Tulane University School of Medicine Changsha, China.

出版信息

Int J Clin Exp Med. 2012;5(4):358-62. Epub 2012 Aug 22.

PMID:22993658
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3443885/
Abstract

The relationship between thyroid and breast diseases has been documented, but the clinical significance of Graves' disease and breast cancer is unclear. We present a young patient with a history of Graves' disease who developed a multicentric infiltrating ductal carcinoma of the breast several months after discontinuing her treatment with propylthiouracil. Early-onset breast cancer in women without a family history of early breast cancer may be related to hyperthyroidism. The relationship between thyroid hormone and estrogen is discussed.

摘要

甲状腺与乳腺疾病之间的关系已有文献记载，但格雷夫斯病与乳腺癌的临床意义尚不清楚。我们报告一名有格雷夫斯病病史的年轻患者，在停用丙硫氧嘧啶治疗数月后发生了多中心浸润性乳腺导管癌。无早期乳腺癌家族史的女性早发性乳腺癌可能与甲状腺功能亢进有关。本文还讨论了甲状腺激素与雌激素之间的关系。

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Early-onset breast cancer in a woman with Graves' disease.一名患有格雷夫斯病的女性的早发性乳腺癌。
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4
[Fluctuations in the titers of anti-thyroid hormone and anti-thyroglobulin antibodies in 4 cases of Graves' disease during long-term treatment period].4例格雷夫斯病患者长期治疗期间抗甲状腺激素和抗甲状腺球蛋白抗体滴度的波动情况
Nihon Naibunpi Gakkai Zasshi. 1989 Jul 20;65(7):627-39. doi: 10.1507/endocrine1927.65.7_627.
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引用本文的文献

1
Thyroid Diseases and Breast Cancer.甲状腺疾病与乳腺癌。
J Pers Med. 2022 Jan 25;12(2):156. doi: 10.3390/jpm12020156.
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TSH receptor antibodies have predictive value for breast cancer - retrospective analysis.促甲状腺激素受体抗体对乳腺癌具有预测价值——回顾性分析。
Thyroid Res. 2013 May 16;6(1):8. doi: 10.1186/1756-6614-6-8.

本文引用的文献

1
Effects of thyroid hormones on human breast cancer cell proliferation.甲状腺激素对人乳腺癌细胞增殖的影响。
J Steroid Biochem Mol Biol. 2008 Mar;109(1-2):57-66. doi: 10.1016/j.jsbmb.2007.12.008. Epub 2007 Dec 7.
2
Thyroid hormone and breast carcinoma. Primary hypothyroidism is associated with a reduced incidence of primary breast carcinoma.甲状腺激素与乳腺癌。原发性甲状腺功能减退与原发性乳腺癌发病率降低有关。
Cancer. 2005 Mar 15;103(6):1122-8. doi: 10.1002/cncr.20881.
3
Thyroid hormone causes mitogen-activated protein kinase-dependent phosphorylation of the nuclear estrogen receptor.甲状腺激素可导致核雌激素受体的丝裂原活化蛋白激酶依赖性磷酸化。
Endocrinology. 2004 Jul;145(7):3265-72. doi: 10.1210/en.2004-0308. Epub 2004 Apr 1.
4
Estrogen-like effects of thyroid hormone on the regulation of tumor suppressor proteins, p53 and retinoblastoma, in breast cancer cells.甲状腺激素对乳腺癌细胞中肿瘤抑制蛋白p53和视网膜母细胞瘤的调节具有雌激素样作用。
Oncogene. 2002 Jan 24;21(5):761-8. doi: 10.1038/sj.onc.1205136.
5
Triiodothyronine mimics the effects of estrogen in breast cancer cell lines.三碘甲状腺原氨酸在乳腺癌细胞系中模拟雌激素的作用。
J Steroid Biochem Mol Biol. 1996 Nov;59(3-4):271-9. doi: 10.1016/s0960-0760(96)00117-3.
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Relationship between breast cancer and thyroid disease: relevance of autoimmune thyroid disorders in breast malignancy.乳腺癌与甲状腺疾病的关系：自身免疫性甲状腺疾病在乳腺恶性肿瘤中的相关性
J Clin Endocrinol Metab. 1996 Mar;81(3):990-4. doi: 10.1210/jcem.81.3.8772562.
7
Ligand-dependent cross-talk between steroid and thyroid hormone receptors. Evidence for common transcriptional coactivator(s).类固醇激素受体与甲状腺激素受体之间的配体依赖性相互作用。共同转录共激活因子的证据。
J Biol Chem. 1996 Jun 21;271(25):14825-33.
8
Radical mastectomy in a patient with coexistent Graves' disease.一位同时患有格雷夫斯病的患者接受了根治性乳房切除术。
Am J Surg. 1976 Jul;132(1):110-1. doi: 10.1016/0002-9610(76)90303-2.
9
Incidence of malignant neoplasms of all types of patients with Graves' disease.各类格雷夫斯病患者恶性肿瘤的发病率。
Arch Intern Med. 1978 Jun;138(6):944-7.
10
Breast cancer in patients with Hashimoto's thyroiditis.桥本甲状腺炎患者的乳腺癌
Lancet. 1975 Dec 6;2(7945):1119-21. doi: 10.1016/s0140-6736(75)91006-5.