Shilikina N P, Yunonin I E, Vinogradov A A, Butusova S V
Ter Arkh. 2012;84(8):29-32.
To study relationships between endothelial activation parameters and inflammatory activity markers in patients with rheumatoid arthritis (RA).
Fifty-three RA patients aged 19 to 62 years were examined. A control group comprised 28 apparently healthy individuals. The markers of endothelial activation, the parameters of RA activity, and their relationship were studied.
There was an elevation in the level of interleukin-8 (IL-8) to 413 (295; 547) pg/ml as compared to the control group 208 (207; 212) pg/ml. In the RA group, the concentration of soluble vascular cell adhesion molecule 1 (sVCAM-1) increased up to 1929 (1297.6; 2739.6) ng/ml whereas in the control group it was 750 (734; 762) ng/ml (p < 0.001). In the patients with RA, the concentration of von Willebrand factor antigen (vWFAg) reached 1.4 (0.8; 1.9) IU/ml; in the control group, it was 0.6 (0.3; 0.8) IU/ml. In the RA group, the level of desquamated endotheliocytes (DE) was higher than that in the control group. Positive correlations were found between the markers of vascular endothelial activation and those of inflammation. There was a positive correlation between C-reactive protein (CRP), rheumatoid factor (RF), sVCAM-1, and DE. Significant positive correlations were observed between DAS28 and the inflammatory markers RF and CRP (R = 0.66; p < 0.05 and R = 0.4; p < 0.05) and the endothelial activation markers sVCAM-1 and vWFAg (R = 0.8; p < 0.05 and R = 0.3; p < 0.05, respectively).
The patients with RA had elevated IL-8, sVCAM-1, and vWFAg levels. Enhanced RA activity resulted in endothelial damage.
研究类风湿关节炎（RA）患者内皮激活参数与炎症活动标志物之间的关系。
对53例年龄在19至62岁的RA患者进行检查。对照组由28名明显健康的个体组成。研究内皮激活标志物、RA活动参数及其之间的关系。
与对照组208（207；212）pg/ml相比，白细胞介素-8（IL-8）水平升高至413（295；547）pg/ml。在RA组中，可溶性血管细胞黏附分子1（sVCAM-1）浓度增加至1929（1297.6；2739.6）ng/ml，而对照组为750（734；762）ng/ml（p<0.001）。在RA患者中，血管性血友病因子抗原（vWFAg）浓度达到1.4（0.8；1.9）IU/ml；对照组为0.6（0.3；0.8）IU/ml。在RA组中，脱落内皮细胞（DE）水平高于对照组。血管内皮激活标志物与炎症标志物之间存在正相关。C反应蛋白（CRP）、类风湿因子（RF）、sVCAM-1和DE之间存在正相关。观察到疾病活动评分28（DAS28）与炎症标志物RF和CRP（R=0.66；p<0.05和R=0.4；p<0.05）以及内皮激活标志物sVCAM-1和vWFAg（分别为R=0.8；p<0.05和R=0.3；p<0.05）之间存在显著正相关。
RA患者的IL-8、sVCAM-1和vWFAg水平升高。RA活动增强导致内皮损伤。
