AVR Consulting Ltd, Northwich, Cheshire, UK.
Int J Cosmet Sci. 2012 Dec;34(6):511-8. doi: 10.1111/j.1468-2494.2012.00752.x. Epub 2012 Sep 21.
This review was initially prepared in 2011 before Professor Johann Wiechers tragically passed away. It has been updated and is being published in his memory. It discusses the importance of mineral oil and its benefits to skin. Its source, structure, properties and efficacy are discussed. Mineral oil has been shown to improve skin softness and barrier function better than some other emollients using the gas-bearing dynamometer and standard water vapour transmission testing as well as in vivo studies showing its effects on suppressing transepidermal water loss (TEWL). It has also been subjected to the rigour of the newer in vivo confocal microscopic measurements now used for testing the performance of moisturizers by following the swelling characteristics of the stratum corneum and been found favourable compared with many vegetable oils. Its introduction as a cosmetic oil was in the late 1800s, and still today, it is used as one of the main components of moisturizers, a true testament to its cost to efficacy window. Naturally, it has physical effects on the stratum corneum, but it is expected that these will translate into biological effects simply through its mechanism of hydrating and occluding the stratum corneum from which many benefits are derived.
这篇综述最初是在 2011 年教授 Johann Wiechers 不幸去世前编写的。经过更新，以纪念他。本文讨论了矿物油的重要性及其对皮肤的益处。讨论了矿物油的来源、结构、性质和功效。使用气体承载测力计和标准水蒸气传输测试以及体内研究，已经证明矿物油比其他一些保湿剂更能改善皮肤的柔软度和屏障功能，抑制经表皮水分流失（TEWL）。它还经受了现在用于测试保湿剂性能的新型体内共聚焦显微镜测量的严格测试，与许多植物油相比，它的表现良好。它作为化妆品油的引入是在 19 世纪后期，直到今天，它仍然是保湿剂的主要成分之一，这充分证明了其成本效益比。当然，它对角质层有物理作用，但人们期望这些作用会通过其滋润和封闭角质层的机制转化为生物作用，从而产生许多益处。
