Charité - Universitätsmedizin Berlin, Department of Dermatology, Venerology and Allergology, Center of Experimental and Applied Cutaneous Physiology, Berlin, Germany.
Skin Res Technol. 2012 Aug;18(3):364-9. doi: 10.1111/j.1600-0846.2011.00578.x. Epub 2011 Nov 14.
The skin represents a potent barrier to the environment, which can be enhanced by the topical application of skin care products, such as oil and oil-based formulations by moisturizing the skin.
The aim of this study was the investigation of the penetration behaviour of four vegetable oils and of paraffin oil into the stratum corneum by laser scanning microscopy. In addition, the occlusion capacity of these substances was assessed by transepidermal water loss (TEWL) measurements. Petrolatum served as a positive control for skin occlusion. The study was conducted in vivo and included six healthy volunteers.
Paraffin oil, as well as the vegetable oils, penetrated only into the first upper layers of the stratum corneum. TEWL measurements indicated that the application of the vegetable oils (except jojoba oil) as well as paraffin oil, led to a similar occlusion of the skin surface. The most effective occlusion was found for petrolatum.
For the investigated oils, a deeper penetration than into the first upper layers of the stratum corneum could be excluded. The decreased TEWL values indicate that the application of the oils leads to a semi-occlusion of the skin surface as it is intended by the use of oils to retain moisture in skin.
皮肤是人体与外界环境之间的强大屏障，通过使用护肤品，如油和油基制剂，可以增强皮肤的保湿功能，从而增强皮肤屏障功能。
本研究的目的是通过激光扫描显微镜研究四种植物油和液体石蜡进入角质层的渗透行为。此外，通过经皮水分流失（TEWL）测量评估这些物质的封闭能力。凡士林作为皮肤封闭的阳性对照。该研究在体内进行，共纳入 6 名健康志愿者。
液体石蜡以及植物油仅渗透进入角质层的最上层。TEWL 测量表明，除霍霍巴油外，植物油（以及液体石蜡）的应用导致皮肤表面的封闭性相似。凡士林的封闭效果最显著。
对于所研究的油类，可排除其穿透角质层进入更深层的可能性。TEWL 值的降低表明，油类的应用可通过半封闭皮肤表面来保留皮肤水分，这也是使用油类的目的。
