Department of Ophthalmology and Research Institute of Medical Sciences, Chonnam National University Medical School and Hospital, Gwangju, Korea.
Acta Ophthalmol. 2013 Feb;91(1):e22-8. doi: 10.1111/j.1755-3768.2012.02538.x. Epub 2012 Sep 20.
To investigate the efficacy of umbilical cord serum eyedrops after laser epithelial keratomileusis (LASEK).
Sixty patients (120 eyes) with myopia who underwent LASEK were studied. Thirty-two patients (64 eyes) were treated with 20% umbilical cord serum eyedrops in combination with conventional treatment (group A), and 28 patients (56 eyes) received conventional treatment only (group B). Epithelial healing time was analysed. Visual acuity, refraction, haze score (0-4) and tear film and ocular surface parameters were evaluated at 1, 2, 4 and 12 weeks after LASEK. The concentration of transforming growth factor (TGF)-β1 in tears was measured with ELISA at 1 week after LASEK.
No significant differences in visual acuity and refraction were found between groups. The mean time to epithelial healing was 3.53 ± 1.19 days in group A and 3.91 ± 1.41 days in group B (p = 0.18). The mean haze scores at 2 and 4 weeks were 0.59 ± 0.80 and 0.31 ± 0.54 in group A and 1.06 ± 0.91 (p = 0.02) and 0.69 ± 0.78 (p = 0.03) in group B. Four and 12 weeks after LASEK, tear film break-up time was longer and keratoepitheliopathy score was lower in group A compared with group B. The mean concentration of TGF-β1 was lower in group A compared with group B (p = 0.01).
Application of 20% umbilical cord serum eyedrops in addition to conventional treatment after LASEK can reduce early postoperative corneal haze and improve tear film and ocular surface parameters.
观察激光上皮下角膜磨镶术（LASEK）后脐带血清滴眼剂的疗效。
对 60 例（120 眼）近视患者行 LASEK，32 例（64 眼）在常规治疗的基础上加用 20%脐带血清滴眼剂（A 组），28 例（56 眼）行单纯常规治疗（B 组）。分析上皮愈合时间，于术后 1、2、4、12 周评估视力、屈光度、角膜混浊评分（0～4 级）和泪膜及眼表参数，术后 1 周采用 ELISA 法检测泪液中转化生长因子（TGF）-β1 浓度。
两组间视力和屈光度差异无统计学意义。A 组上皮愈合时间平均为 3.53±1.19 天，B 组为 3.91±1.41 天（p=0.18）。A 组术后 2、4 周角膜混浊评分分别为 0.59±0.80 和 0.31±0.54，B 组分别为 1.06±0.91（p=0.02）和 0.69±0.78（p=0.03）；A 组术后 4、12 周泪膜破裂时间较 B 组长，眼表疾病指数较 B 组低。A 组 TGF-β1 浓度低于 B 组（p=0.01）。
LASEK 术后应用 20%脐带血清滴眼剂辅助治疗可减轻术后早期角膜混浊，改善泪膜和眼表参数。
