Department of Statistics, University of Washington, Seattle, Washington 98195, USA.
Annu Rev Genet. 2012;46:617-33. doi: 10.1146/annurev-genet-110711-155534. Epub 2012 Sep 17.
Short segments of identity by descent (IBD) between individuals with no known relationship can be detected using genome-wide single nucleotide polymorphism data and recently developed statistical methodology. Emerging applications for the detected IBD segments include IBD mapping, haplotype phase inference, genotype imputation, and inference of population structure. In this review, we explain the principles behind methods for IBD segment detection, describe recently developed methods, discuss approaches to comparing methods, and give an overview of applications.
短片段的血缘同一性（IBD）在没有已知关系的个体之间可以通过全基因组单核苷酸多态性数据和最近开发的统计方法检测到。已检测到的 IBD 片段的新兴应用包括 IBD 图谱绘制、单倍型相位推断、基因型推断和群体结构推断。在这篇综述中，我们解释了 IBD 片段检测方法背后的原理，描述了最近开发的方法，讨论了比较方法的方法，并概述了应用。
