Department of Chemistry, University of Nebraska-Lincoln, Lincoln, Nebraska 68588-0304, United States.
J Org Chem. 2013 Jan 4;78(1):42-7. doi: 10.1021/jo3015775. Epub 2012 Oct 2.
Several variants of reductive ozonolysis, defined here as the in situ generation of aldehydes or ketones during ozonolytic cleavage of alkenes, are demonstrated to work effectively in tandem with a number of C-C bond-forming reactions. For reactions involving basic nucleophiles (1,2-addition of Grignard reagents, Wittig or Horner-Emmons olefinations, and directed aldol reactions of lithium enolates), the one-pot process offers a rapid and high-yielding alternative to traditional two-step protocols.
几种还原臭氧化方法，在这里定义为在烯烃臭氧化裂解过程中醛或酮的原位生成，被证明可与许多 C-C 键形成反应有效地串联使用。对于涉及碱性亲核试剂的反应（格氏试剂的 1,2-加成、Wittig 或 Horner-Emmons 烯烃化以及锂烯醇化物的定向醛醇反应），一锅法提供了比传统两步法更快速、高产率的替代方法。
