Forsyth G W, Hamilton D L, Scoot A, Goertz K E, Kapitany R A
Can J Physiol Pharmacol. 1979 Sep;57(9):1004-10. doi: 10.1139/y79-150.
The feasibility of reducing intestinal secretion by the use of agents which decrease intestinal mucosal cAMP concentration has been investigated in the weanling pig and the rabbit. Three different agents for decreasing mucosal cAMP concentration were studied. The cyclic nucleotide phosphodiesterase activator, imidazole, significantly reduced mucosal cAMP concentrations only in the weanling pig. Intraluminal 2'-deoxyadenosine-3'AMP inhibited adenylate cyclase and caused a decrease in mucosal cAMP concentration in both the pig and the rabbit. The introduction of the heat-stable enterotoxin of Escherichia coli into pig jejunal segments also gave lowered mucosal cAMP concentrations. While these three agents effectively reduced cAMP concentrations in intestinal mucosa, they were ineffective in reducing the net fluid secretory effects of cholera toxin. Secretion caused by cholera toxin apparently persists independent of the temporary changes in cAMP concentration which can be induced by pharmacological agents.
在断奶仔猪和兔子身上研究了使用降低肠道黏膜环磷酸腺苷（cAMP）浓度的药物来减少肠道分泌的可行性。研究了三种不同的降低黏膜cAMP浓度的药物。环核苷酸磷酸二酯酶激活剂咪唑仅在断奶仔猪中显著降低了黏膜cAMP浓度。肠腔内的2'-脱氧腺苷-3'AMP抑制腺苷酸环化酶，并导致猪和兔子的黏膜cAMP浓度降低。将大肠杆菌的热稳定肠毒素引入猪空肠段也使黏膜cAMP浓度降低。虽然这三种药物有效地降低了肠道黏膜中的cAMP浓度，但它们在降低霍乱毒素的净液体分泌作用方面无效。霍乱毒素引起的分泌显然持续存在，与药物可诱导的cAMP浓度的暂时变化无关。
