烟酸可抑制猪小肠毒素诱导的空肠分泌。
Nicotinic acid inhibits enterotoxin-induced jejunal secretion in the pig.
作者信息
Forsyth G W, Kapitany R A, Scoot A
出版信息
Can J Comp Med. 1981 Apr;45(2):167-72.
The use of nicotinic acid for preventing intestinal secretion caused by cholera toxin and by the heat-stable enterotoxin of Escherichia coli has been investigated in the weanling pig. Secretory effects were measured in ligated jejunal loops of halothane-anesthetized pigs by dilution of a nonabsorbable marker added to the loop fluid. Different routes of administration and different initial pH values for nicotinate solutions were studied to determine optimal conditions for secretory inhibition. The neutral sodium salt of nicotinic acid had no significant antisecretory activity under any conditions used in these trials. Inhibition of secretion was most effective with partly neutralized nicotinic acid at pH 4.5 added directly to loops containing enterotoxin. Net fluid secretion induced by cholera toxin or heat-stable enterotoxin of E. coli was prevented by this treatment. Reversal of secretion was not accompanied by any measurable changes in cyclic nucleotide concentration in intestinal mucosa. Nicotinic acid antagonism of a secretory step common to cholera toxin and heat-stable enterotoxin of E. coli but subsequent to cyclic nucleotide involvement is indicated by these data.
已在断奶仔猪中研究了烟酸用于预防霍乱毒素和大肠杆菌热稳定肠毒素引起的肠道分泌的情况。通过稀释添加到肠袢液中的不可吸收标记物，在氟烷麻醉猪的结扎空肠袢中测量分泌效应。研究了烟酸溶液的不同给药途径和不同初始pH值，以确定分泌抑制的最佳条件。在这些试验所使用的任何条件下，烟酸的中性钠盐均无显著的抗分泌活性。当pH值为4.5的部分中和烟酸直接添加到含有肠毒素的肠袢中时，分泌抑制效果最为显著。这种处理可防止霍乱毒素或大肠杆菌热稳定肠毒素诱导的净液体分泌。分泌的逆转并未伴随着肠黏膜中环状核苷酸浓度的任何可测量变化。这些数据表明，烟酸对霍乱毒素和大肠杆菌热稳定肠毒素共同的分泌步骤具有拮抗作用，但该步骤发生在环状核苷酸参与之后。
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