Duan Xiao-Li, Gong Heng, Zeng Xian-Tao, Ni Xiao-Bing, Yan Yan, Chen Wen, Liu Guo-Lei
Department of Digestion Medcine, Taihe Hospital, Hubei University of Medcine, Shiyan, Hubei Province, China.
Asian Pac J Cancer Prev. 2012;13(7):3299-303. doi: 10.7314/apjcp.2012.13.7.3299.
To investigate the association between xeroderma pigmentosum group D (XPD) Asp312Asn polymorphism and esophageal cancer (EC) susceptibility by meta-analysis.
We searched PubMed up to April 9th, 2012, to identify relevant papers, and 8 published case-control studies including 2165 EC patients and 3141 healthy controls were yielded. Odds ratios (ORs) with relevant 95% confidence intervals (CIs) were applied to assess the association between XPD Asp312Asn polymorphism and EC susceptibility with the Comprehensive Meta-Analysis software, version 2.2.
Overall, the meta-analysis results suggested the XPD Asp312Asn polymorphism to be significantly associated with EC susceptibility [(Asn/Asn+Asp/Asn) vs. Asp/Asp: OR=1.20, 95%CI=1.05-1.36, p=0.01; and Asp/Asn vs. Asp/Asp: OR=1.15, 95%CI=1.01-1.31, p=0.04]. In the subgroup analysis by ethnicity and cancer type, significantly associations were found for Caucasian populations [(Asn/Asn+Asp/Asn) vs. Asp/Asp: OR=1.26, 95%CI=1.08-1.47, p<0.001; Asp/Asn vs. Asp/Asp: OR=1.19, 95%CI=1.02- 1.40, p=0.03] and esophageal squamous cell carcinoma [(Asn/Asn+Asp/Asn) vs. Asp/Asp: OR=1.19, 95%CI=1.01-1.41, p=0.04]. There was no heterogeneity and no publication bias existed.
This meta-analysis shows that the XPD Asp312Asn polymorphism may be a risk factor for developing EC, especially for Caucasian populations and esophageal squamous cell carcinoma.
通过荟萃分析研究着色性干皮病D组（XPD）Asp312Asn多态性与食管癌（EC）易感性之间的关联。
检索截至2012年4月9日的PubMed以确定相关论文，共获得8项已发表的病例对照研究，包括2165例EC患者和3141例健康对照。使用综合荟萃分析软件2.2版应用比值比（OR）及相关的95%置信区间（CI）来评估XPD Asp312Asn多态性与EC易感性之间的关联。
总体而言，荟萃分析结果表明XPD Asp312Asn多态性与EC易感性显著相关[（Asn/Asn + Asp/Asn）与Asp/Asp相比：OR = 1.20，95%CI = 1.05 - 1.36，p = 0.01；Asp/Asn与Asp/Asp相比：OR = 1.15，95%CI = 1.01 - 1.31，p = 0.04]。在按种族和癌症类型进行的亚组分析中，发现白种人群[（Asn/Asn + Asp/Asn）与Asp/Asp相比：OR = 1.26，95%CI = 1.08 - 1.47，p < 0.001；Asp/Asn与Asp/Asp相比：OR = 1.19，95%CI = 1.02 - 1.40，p = 0.03]和食管鳞状细胞癌[（Asn/Asn + Asp/Asn）与Asp/Asp相比：OR = 1.19，95%CI = 1.01 - 1.41，p = 0.04]存在显著关联。不存在异质性和发表偏倚。
这项荟萃分析表明，XPD Asp312Asn多态性可能是发生EC的一个危险因素，尤其是对白种人群和食管鳞状细胞癌而言。
