Department of Stomatology, Taihe Hospital, Hubei University of Medicine, Shiyan, People's Republic of China.
PLoS One. 2012;7(4):e35220. doi: 10.1371/journal.pone.0035220. Epub 2012 Apr 20.
To investigate the association between XPD Asp312Asn polymorphism and head and neck cancer risk through this meta-analysis.
We performed a meta-analysis of 9 published case-control studies including 2,670 patients with head and neck cancer and 4,452 controls. An odds ratio (OR) with a 95% confidence interval (CI) was applied to assess the association between XPD Asp312Asn polymorphism and head and neck cancer risk.
Overall, no significant association between XPD Asp312Asn polymorphism and head and neck cancer risk was found in this meta-analysis (Asn/Asn vs. Asp/Asp: OR = 0.95, 95%CI = 0.80-1.13, P = 0.550, P(heterogeneity) = 0.126; Asp/Asn vs. Asp/Asp: OR = 1.11, 95%CI = 0.99-1.24, P = 0.065, P(heterogeneity) = 0.663; Asn/Asn+Asp/Asn vs. Asp/Asp: OR = 1.07, 95%CI = 0.97-1.19, P = 0.189, P(heterogeneity) = 0.627; Asn/Asn vs. Asp/Asp+Asp/Asn: OR = 0.87, 95%CI = 0.68-1.10, P = 0.243, P(heterogeneity) = 0.089). In the subgroup analysis by HWE, ethnicity, and study design, there was still no significant association detected in all genetic models.
This meta-analysis demonstrates that XPD Asp312Asn polymorphism may not be a risk factor for developing head and neck cancer.
通过这项荟萃分析研究 XPD Asp312Asn 多态性与头颈部癌症风险之间的关联。
我们对 9 项已发表的病例对照研究进行了荟萃分析，共纳入 2670 例头颈部癌症患者和 4452 例对照。应用优势比（OR）及其 95%置信区间（CI）评估 XPD Asp312Asn 多态性与头颈部癌症风险之间的关联。
总体而言，这项荟萃分析未发现 XPD Asp312Asn 多态性与头颈部癌症风险之间存在显著关联（Asn/Asn 与 Asp/Asp：OR=0.95，95%CI=0.80-1.13，P=0.550，P（异质性）=0.126；Asp/Asn 与 Asp/Asp：OR=1.11，95%CI=0.99-1.24，P=0.065，P（异质性）=0.663；Asn/Asn+Asp/Asn 与 Asp/Asp：OR=1.07，95%CI=0.97-1.19，P=0.189，P（异质性）=0.627；Asn/Asn 与 Asp/Asp+Asp/Asn：OR=0.87，95%CI=0.68-1.10，P=0.243，P（异质性）=0.089）。在根据 HWE、种族和研究设计进行的亚组分析中，所有遗传模型均未检测到显著关联。
这项荟萃分析表明，XPD Asp312Asn 多态性可能不是头颈部癌症发生的危险因素。
