Bunjhoo Hansvin, Wang Zheng-Yun, Chen Hui-Long, Cheng Sheng, Xiong Wei-Ning, Xu Yong-Jian, Cao Yong
Department of Respiratory and Critical Care Medicine, Tongji Hospital, Key Laboratory of Pulmonary Diseases of the Ministry of Health of China, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Asian Pac J Cancer Prev. 2012;13(7):3495-9. doi: 10.7314/apjcp.2012.13.7.3495.
The aim of this study was to evaluate the diagnostic value of interleukin 21 (IL-21) and carcinoembryonic antigen (CEA) in tuberculous pleural effusions (TPEs) and malignant pleural effusions (MPEs). Pleural effusion samples from 103 patients were classified on the basis of diagnosis as TPE (n=51) and MPE (n=52). The concentration of IL-21 was determined by ELISA. Lactate dehydrogenase (LDH), adenosine dehydrogenase (ADA) and CEA levels were also determined in all patients. A significant difference was observed in the levels of ADA and CEA (P<0.01), but not in the levels of LDH (P>0.05) between TPE and MPE. The concentration of IL-21 in MPE was significantly higher compared to TPE (P<0.01). With a threshold value of 4.32 pg/ml, IL-21 had a sensitivity of 76.9% (40/52) and a specificity of 80.4% (41/51). Combined detection of IL-21 and CEA had a sensitivity of 69.2% (36/52) and a specificity of 92.2% (47/51). These two markers can contribute to the differential diagnosis of MPEs.
本研究旨在评估白细胞介素21（IL-21）和癌胚抗原（CEA）在结核性胸腔积液（TPE）和恶性胸腔积液（MPE）中的诊断价值。将103例患者的胸腔积液样本根据诊断分为TPE（n = 51）和MPE（n = 52）。采用酶联免疫吸附测定法（ELISA）测定IL-21浓度。还测定了所有患者的乳酸脱氢酶（LDH）、腺苷脱氢酶（ADA）和CEA水平。TPE和MPE之间ADA和CEA水平存在显著差异（P<0.01），但LDH水平无显著差异（P>0.05）。MPE中IL-21浓度显著高于TPE（P<0.01）。以4.32 pg/ml为阈值，IL-21的灵敏度为76.9%（40/52），特异性为80.4%（41/51）。IL-21和CEA联合检测的灵敏度为69.2%（36/52），特异性为92.2%（47/51）。这两种标志物有助于MPE的鉴别诊断。
