Jin DI, Chen Ying, Wang Zhengyun, Wang Siwei, Bunjhoo Hansvin, Zhu Jing, Cao Yong, Xiong Weining, Xiong Shengdao, Xu Yongjian, Fang Huijuan
Department of Respiratory Disease, Tongji Hospital, Key Lab of Pulmonary Diseases of Health Ministry, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030;
Exp Ther Med. 2011 Nov;2(6):1205-1209. doi: 10.3892/etm.2011.344. Epub 2011 Aug 25.
The aim of this study was to investigate the diagnostic value of interleukin 22 (IL-22) and carcinoembryonic antigen (CEA) in tuberculous pleural effusions (TPEs) and malignant pleural effusions (MPEs). Pleural effusion samples from 56 patients were classified on the basis of diagnosis as TPE (n=28) and MPE (n=28). The concentration of IL-22 was determined by ELISA. Lactate dehydrogenase (LDH), adenosine dehydrogenase (ADA) and CEA levels were also determined in all patients. A significant difference was observed in the levels of ADA and CEA (P<0.01), but not in the levels of LDH (P>0.05) between TPE and MPE. The concentration of IL-22 in TPE was significantly higher compared to MPE (P<0.01). With a threshold value of 49 pg/ml, IL-22 had a sensitivity of 82.14% (23/28) and a specificity of 96.43% (27/28) for differential diagnosis. The combined detection of IL-22 and CEA had a sensitivity of 100% (28/28) and a specificity of 96.43% (27/28) to distinguish TPE from MPE. TPEs showed significantly higher levels of IL-22 compared to MPEs. The combined detection of IL-22 and CEA may be more valuable in the differential diagnosis between TPE and MPE.
本研究的目的是探讨白细胞介素22（IL-22）和癌胚抗原（CEA）在结核性胸腔积液（TPE）和恶性胸腔积液（MPE）中的诊断价值。将56例患者的胸腔积液样本根据诊断分为TPE组（n = 28）和MPE组（n = 28）。采用酶联免疫吸附测定法（ELISA）测定IL-22的浓度。同时测定所有患者的乳酸脱氢酶（LDH）、腺苷脱氢酶（ADA）和CEA水平。TPE组和MPE组之间ADA和CEA水平存在显著差异（P<0.01），但LDH水平无显著差异（P>0.05）。TPE组中IL-22的浓度显著高于MPE组（P<0.01）。以49 pg/ml为临界值，IL-22鉴别诊断的灵敏度为82.14%（23/28），特异度为96.43%（27/28）。IL-22和CEA联合检测鉴别TPE和MPE的灵敏度为100%（28/28），特异度为96.43%（27/28）。与MPE相比，TPE中IL-22水平显著更高。IL-22和CEA联合检测在TPE和MPE的鉴别诊断中可能更有价值。
