Tulane University Heart and Vascular Institute, Tulane University School of Medicine, New Orleans, LA 70112, USA.
J Womens Health (Larchmt). 2012 Oct;21(10):1053-8. doi: 10.1089/jwh.2011.3388. Epub 2012 Sep 20.
Previous studies evaluating breast arterial calcifications (BAC) as a risk marker for coronary artery disease (CAD) have been limited by sample size and have yielded mixed results. Our objective was to evaluate the association of BAC and CAD.
Data sources included Medline (1970-2010), the Cochrane Controlled Trials Register electronic database (1970-2010), and CINAHL (1970-2010). The search strategy included the keywords, breast artery calcification, vascular calcification on mammogram, coronary angiography, and meta-analysis. Eligible studies included female patients who had undergone coronary angiography, the gold standard for diagnosing CAD, and had screening mammograms that revealed the presence or absence of BAC. Information on eligibility criteria, baseline characteristics, results, and methodologic quality was extracted by two reviewers. Disagreements were resolved by consensus.
A total of 927 patients were enrolled in the five studies. There was a 1.59 (95% confidence interval [CI] 1-21-2.09) increased odds of angiographically defined CAD in patients with BAC seen on mammography.
The presence of BAC on mammography appears to increase the risk of having obstructive CAD on coronary angiography; thus, BAC may not be a benign finding.
以前评估乳腺动脉钙化（BAC）作为冠心病（CAD）风险标志物的研究因样本量有限而受到限制，并且结果不一。我们的目的是评估 BAC 和 CAD 之间的关联。
资料来源包括 Medline（1970-2010 年）、Cochrane 对照试验注册电子数据库（1970-2010 年）和 CINAHL（1970-2010 年）。搜索策略包括以下关键词：乳腺动脉钙化、乳房 X 线照相术上的血管钙化、冠状动脉造影术和荟萃分析。合格的研究包括接受冠状动脉造影术（诊断 CAD 的金标准）且乳房 X 光片显示存在或不存在 BAC 的女性患者。两名评审员提取了关于合格标准、基线特征、结果和方法学质量的信息。意见分歧通过协商解决。
五项研究共纳入 927 名患者。在乳房 X 光片上发现 BAC 的患者中，经血管造影术定义的 CAD 的发生几率增加 1.59 倍（95%置信区间 [CI] 1-21-2.09）。
乳房 X 光片上出现 BAC 似乎会增加冠状动脉造影术上存在阻塞性 CAD 的风险；因此，BAC 可能不是良性发现。
