采用 Etest 法检测明确的碳青霉烯类耐药机制对多利培南与阿米卡星、黏菌素和左氧氟沙星体外协同作用的影响。
In vitro Etest synergy of doripenem with amikacin, colistin, and levofloxacin against Pseudomonas aeruginosa with defined carbapenem resistance mechanisms as determined by the Etest method.
机构信息
Janssen Pharmaceutical Research and Development, Raritan, NJ 08869, USA.
出版信息
Diagn Microbiol Infect Dis. 2012 Dec;74(4):417-9. doi: 10.1016/j.diagmicrobio.2012.08.014. Epub 2012 Sep 17.
Abstract
The applicability of Etest for synergy testing was evaluated in 100 carbapenem-nonsusceptible Pseudomonas aeruginosa isolates. Combinations of doripenem with amikacin, colistin, or levofloxacin were synergistic or additive against 67%, 31%, and 23% of isolates, respectively. The use of Etest was practical to evaluate the synergy of doripenem with other antipseudomonal agents.
摘要
我们评估了 Etest 在 100 株耐碳青霉烯类铜绿假单胞菌中的协同作用检测适用性。多利培南与阿米卡星、黏菌素或左氧氟沙星联合使用对 67%、31%和 23%的分离株分别表现出协同或相加作用。Etest 可用于评估多利培南与其他抗假单胞菌药物的协同作用。
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