Division of Mathematics, University of Dundee, Dundee, Scotland.
Biophys J. 2012 Sep 19;103(6):1141-51. doi: 10.1016/j.bpj.2012.07.048.
Cell migration is vitally important in a wide variety of biological contexts ranging from embryonic development and wound healing to malignant diseases such as cancer. It is a very complex process that is controlled by intracellular signaling pathways as well as the cell's microenvironment. Due to its importance and complexity, it has been studied for many years in the biomedical sciences, and in the last 30 years it also received an increasing amount of interest from theoretical scientists and mathematical modelers. Here we propose a force-based, individual-based modeling framework that links single-cell migration with matrix fibers and cell-matrix interactions through contact guidance and matrix remodelling. With this approach, we can highlight the effect of the cell's environment on its migration. We investigate the influence of matrix stiffness, matrix architecture, and cell speed on migration using quantitative measures that allow us to compare the results to experiments.
细胞迁移在从胚胎发育和伤口愈合到癌症等恶性疾病等广泛的生物学背景下至关重要。它是一个非常复杂的过程，受到细胞内信号通路以及细胞微环境的控制。由于其重要性和复杂性，它在生物医学科学中已经被研究了很多年，并且在过去的 30 年中，它也受到了理论科学家和数学建模者越来越多的关注。在这里，我们提出了一个基于力的、基于个体的建模框架，通过接触导向和基质重塑将单细胞迁移与基质纤维和细胞-基质相互作用联系起来。通过这种方法，我们可以突出细胞环境对其迁移的影响。我们使用定量测量来研究基质刚度、基质结构和细胞速度对迁移的影响，这使我们能够将结果与实验进行比较。
