Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, China.
Bioorg Med Chem Lett. 2012 Oct 15;22(20):6358-61. doi: 10.1016/j.bmcl.2012.08.077. Epub 2012 Aug 27.
N-(rhodamine B)-deoxylactam-5-amino-1-pentanol (dRB-APOH) was designed and prepared as the chromo-fluorogenic sensor for detection of a nerve agent simulant via analyte triggered tandem phosphorylation and opening of the intramolecular deoxylactam. The successful detection of diethyl chlorophosphate suggests the utility of rhodamine-deoxylactams as the chromo-fluorogenic signal reporting platform for design of sensors targeting reactive chemical species via various chemistries.
N-（若丹明 B）-去氧乳清酸-5-氨基-1-戊醇（dRB-APOH）被设计并制备为用于通过分析物触发的串联磷酸化和分子内去氧乳清酸的开环来检测神经毒剂模拟物的显色荧光传感器。成功检测到二乙基氯膦酸表明，若丹明去氧乳清酸可作为显色荧光信号报告平台，用于通过各种化学方法设计针对反应性化学物质的传感器。
