Section of Inflammation and Signal Transduction, Department of Medicine, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK.
Trends Cell Biol. 2012 Nov;22(11):557-66. doi: 10.1016/j.tcb.2012.08.001. Epub 2012 Sep 18.
Nuclear factor kappa B (NF-κB) transcription factors are evolutionarily conserved, coordinating regulators of immune and inflammatory responses. They also play a pivotal role in oncogenesis and metabolic disorders. Several studies during the past two decades have highlighted the key role of the IKK/NF-κB pathway in the induction and maintenance of the state of inflammation that underlies metabolic diseases such as obesity and type 2 diabetes. Recent reports, however, reveal an even more intimate connection between NF-κB and metabolism. These studies demonstrate that NF-κB regulates energy homeostasis via direct engagement of the cellular networks governing glycolysis and respiration, with profound implications beyond metabolic diseases, including cancer, ageing and anticancer therapy. In this review, we discuss these emerging bioenergetic functions of NF-κB and their significance to oncogenesis.
核因子 kappa B（NF-κB）转录因子是进化上保守的，协调免疫和炎症反应的调节剂。它们在肿瘤发生和代谢紊乱中也起着关键作用。过去二十年的几项研究强调了 IKK/NF-κB 途径在诱导和维持肥胖和 2 型糖尿病等代谢疾病基础炎症状态中的关键作用。然而，最近的报告揭示了 NF-κB 与代谢之间更密切的联系。这些研究表明，NF-κB 通过直接参与调节糖酵解和呼吸的细胞网络来调节能量稳态，其意义不仅限于代谢疾病，还包括癌症、衰老和抗癌治疗。在这篇综述中，我们讨论了 NF-κB 的这些新兴生物能功能及其对肿瘤发生的意义。
