苦马酸衍生物的合成及凋亡活性
Tormentic acid derivatives: synthesis and apoptotic activity.
机构信息
Bereich Organische Chemie, Martin-Luther Universität Halle-Wittenberg, Kurt-Mothes-Str. 2, D-06120 Halle (Saale), Germany.
出版信息
Eur J Med Chem. 2012 Oct;56:237-45. doi: 10.1016/j.ejmech.2012.08.032. Epub 2012 Aug 31.
PMID:22995818
Abstract
Several derivatives of tormentic acid have been prepared and tested for their antitumor activity. The dichloroacetate 14 is an excellent antitumor active agent acting by an apoptose inducing pathway as demonstrated by OA/PI staining, DNA laddering experiments as well as by an annexin V binding assay.
摘要
已经制备了几种苦木酮衍生物并对其进行了抗肿瘤活性测试。二氯乙酸酯 14 是一种具有优异抗肿瘤活性的试剂，通过 OA/PI 染色、DNA 梯状实验以及 annexin V 结合实验证明其通过诱导细胞凋亡发挥作用。
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