Department of Tissue Engineering & Applied Cell Science, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Nano Drug Delivery Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Nanomedicine (Lond). 2024;19(23):1931-1951. doi: 10.1080/17435889.2024.2377063. Epub 2024 Aug 15.
Despite the development of new generations of antibiotics, vancomycin remained as a high-efficacy antibiotic for treating the infections caused by MRSA. Researchers have explored various nanoformulations, aiming to enhance the therapeutic efficacy of vancomycin. Such novel formulations improve the effectiveness of drug cargoes in treating bacterial infections and minimizing the risk of adverse effects. The vast of researches have focuses on enhancing the permeation ability of vancomycin through different biological barriers especially those of gastrointestinal tract. Increasing the drug loading and tuning the drug release from nanocarrier are other important goal for many conducted studies. This study reviews the newest nano-based formulations for vancomycin as a key antibiotic in treating hospitalized bacterial infections.
尽管新一代抗生素不断发展，万古霉素仍然是治疗耐甲氧西林金黄色葡萄球菌（MRSA）感染的高效抗生素。研究人员探索了各种纳米制剂，旨在提高万古霉素的治疗效果。这些新型制剂提高了药物有效载荷治疗细菌感染的效果，并最大限度地降低了不良反应的风险。大量的研究集中在通过不同的生物屏障（特别是胃肠道）增强万古霉素的渗透能力上。提高药物载药量和调整纳米载体的药物释放也是许多研究的重要目标。本研究综述了作为治疗住院细菌感染的关键抗生素的万古霉素的最新纳米制剂。
