心理社会因素与心钠肽的关系：血管健康的标志物。

Psychosocial correlates of atrial natriuretic peptide: a marker of vascular health.

机构信息

Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA.

出版信息

Ann Behav Med. 2013 Feb;45(1):99-109. doi: 10.1007/s12160-012-9414-1.

DOI:10.1007/s12160-012-9414-1

PMID:22996638

Abstract

BACKGROUND

Psychosocial factors have been associated with cardiovascular outcomes, but few studies have examined the association between psychosocial function and natriuretic peptides.

PURPOSE

The purpose of this study is to determine the predictive value of hostility, anger, and social support in relation to atrial natriuretic peptide (ANP), a marker of vascular health, among middle-aged men.

METHODS

One hundred twenty-one men (mean age = 39.8 years, SD = 4.1) underwent assessments of ANP and completed the Cook-Medley Hostility Scale, the Spielberger State-Trait Anger Scale, and the Interview Schedule for Social Interaction.

RESULTS

Higher levels of hostility (β = 0.22 [95 % CI 0.04, 0.40], P = 0.032) and trait anger (β = 0.18 [95 % CI 0.01, 0.37], P = 0.044) were associated with greater ANP levels. In contrast, higher perceived social support was also associated with lower ANP levels, (β = -0.19 [95 % CI -0.05, -0.41], P = 0.010).

CONCLUSIONS

Psychosocial factors, including hostility, anger, and social support, are associated with varying ANP levels among middle-aged men, independent of cardiovascular and behavioral risk factors.

摘要

背景

社会心理因素与心血管结局相关，但很少有研究探讨社会心理功能与利钠肽之间的关系。

目的

本研究旨在确定敌意、愤怒和社会支持与中年男性血管健康标志物心房利钠肽（ANP）之间的关系，以及它们对 ANP 的预测价值。

方法

121 名男性（平均年龄=39.8 岁，标准差=4.1）接受了 ANP 评估，并完成了库克-梅德利敌意量表、斯皮尔伯格状态-特质愤怒量表和社会互动访谈表。

结果

较高的敌意水平（β=0.22[95%置信区间 0.04，0.40]，P=0.032）和特质愤怒（β=0.18[95%置信区间 0.01，0.37]，P=0.044）与更高的 ANP 水平相关。相反，较高的感知社会支持也与较低的 ANP 水平相关（β=-0.19[95%置信区间-0.05，-0.41]，P=0.010）。