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Development of a continuous dissolution/absorption system--a technical note.

作者信息

Gao Zongming

机构信息

Division of Pharmaceutical Analysis, Center for Drug Evaluation and Research, Food and Drug Administration, St. Louis, Missouri 63101, USA.

出版信息

AAPS PharmSciTech. 2012 Dec;13(4):1287-92. doi: 10.1208/s12249-012-9856-6. Epub 2012 Sep 21.

DOI:10.1208/s12249-012-9856-6
PMID:22996672
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3513438/
Abstract
摘要

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AAPS PharmSciTech. 2012 Dec;13(4):1287-92. doi: 10.1208/s12249-012-9856-6. Epub 2012 Sep 21.
2
Location, location, location: gastrointestinal delivery site and its impact on absorption.位置，位置，还是位置：胃肠道给药部位及其对吸收的影响。
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Role of nanotechnology in pharmaceutical product development.纳米技术在药品研发中的作用。
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Estimating drug solubility in the gastrointestinal tract.估算药物在胃肠道中的溶解度。
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Dissolution Testing for Bioavailability of Over-the-Counter (OTC) Drugs--a Technical Note.非处方药（OTC）生物利用度的溶出度测试——技术说明
AAPS PharmSciTech. 2015 Oct;16(5):1227-33. doi: 10.1208/s12249-015-0297-x. Epub 2015 Feb 14.
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Biorelevant in vitro performance testing of orally administered dosage forms-workshop report.口服剂型的生物相关体外性能测试——研讨会报告
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本文引用的文献

1
An investigation into the utility of a multi-compartmental, dynamic, system of the upper gastrointestinal tract to support formulation development and establish bioequivalence of poorly soluble drugs.研究一种多隔室、动态的上胃肠道系统在支持制剂开发和确定难溶性药物生物等效性方面的实用性。
AAPS J. 2012 Jun;14(2):196-205. doi: 10.1208/s12248-012-9333-x. Epub 2012 Feb 29.
2
Application of dissolution/permeation system for evaluation of formulation effect on oral absorption of poorly water-soluble drugs in drug development.用于评价制剂对难溶性药物口服吸收影响的溶出/渗透系统在药物开发中的应用。
Pharm Res. 2012 Jun;29(6):1485-94. doi: 10.1007/s11095-011-0623-2. Epub 2011 Dec 2.
3
In vitro dissolution/permeation system to predict the oral absorption of poorly water-soluble drugs: effect of food and dose strength on it.体外溶出/渗透系统预测难溶性药物的口服吸收：食物和剂量强度的影响。
Biol Pharm Bull. 2011;34(3):401-7. doi: 10.1248/bpb.34.401.
4
Physiological parameters for oral delivery and in vitro testing.口服给药和体外测试的生理参数。
Mol Pharm. 2010 Oct 4;7(5):1388-405. doi: 10.1021/mp100149j. Epub 2010 Sep 7.
5
Permeability assessment for solid oral drug formulations based on Caco-2 monolayer in combination with a flow through dissolution cell.基于Caco-2单层细胞并结合流通式溶出池的固体口服药物制剂渗透性评估。
Eur J Pharm Biopharm. 2007 May;66(2):286-95. doi: 10.1016/j.ejpb.2006.10.015. Epub 2006 Oct 28.
6
A century of dissolution research: from Noyes and Whitney to the biopharmaceutics classification system.一个世纪的溶出度研究：从诺伊斯和惠特尼到生物药剂学分类系统。
Int J Pharm. 2006 Sep 14;321(1-2):1-11. doi: 10.1016/j.ijpharm.2006.07.011. Epub 2006 Jul 15.
7
Predicting drug disposition via application of BCS: transport/absorption/ elimination interplay and development of a biopharmaceutics drug disposition classification system.通过应用生物药剂学分类系统（BCS）预测药物处置：转运/吸收/消除的相互作用及生物药剂学药物处置分类系统的建立
Pharm Res. 2005 Jan;22(1):11-23. doi: 10.1007/s11095-004-9004-4.
8
In vitro system to evaluate oral absorption of poorly water-soluble drugs: simultaneous analysis on dissolution and permeation of drugs.评估难溶性药物口服吸收的体外系统：药物溶出与渗透的同步分析
Pharm Res. 2003 Oct;20(10):1674-80. doi: 10.1023/a:1026107906191.
9
A comparative study of artificial membrane permeability assay for high throughput profiling of drug absorption potential.用于药物吸收潜力高通量分析的人工膜通透性测定的比较研究
Eur J Med Chem. 2002 May;37(5):399-407. doi: 10.1016/s0223-5234(02)01360-0.
10
Prediction of dissolution-absorption relationships from a continuous dissolution/Caco-2 system.基于连续溶出/Caco-2系统预测溶出-吸收关系
AAPS PharmSci. 1999;1(2):E3. doi: 10.1208/ps010203.