Westfälische Wilhelms-Universität Münster, Organisch-Chemisches Institut, Corrensstrasse 40, 48149 Münster, Germany.
Angew Chem Int Ed Engl. 2012 Oct 8;51(41):10236-54. doi: 10.1002/anie.201203269. Epub 2012 Sep 20.
The use of coordinating moieties as directing groups for the functionalization of aromatic C-H bonds has become an established tool to enhance reactivity and induce regioselectivity. Nevertheless, with regard to the synthetic applicability of C-H activation, there is a growing interest in transformations in which the directing group can be fully abandoned, thus allowing the direct functionalization of simple benzene derivatives. However, this approach requires the disclosure of new strategies to achieve reactivity and to control selectivity. In this review, recent advances in the emerging field of non-chelate-assisted C-H activation are discussed, highlighting some of the most intriguing and inspiring examples of induction of reactivity and selectivity.
将配位基团用作芳香 C-H 键功能化的导向基团已成为增强反应性和诱导区域选择性的一种既定工具。然而，就 C-H 活化的合成适用性而言，人们越来越感兴趣的是可以完全放弃导向基团的转化，从而允许简单苯衍生物的直接官能化。但是，这种方法需要揭示新的策略来实现反应性并控制选择性。在这篇综述中，讨论了新兴的非螯合辅助 C-H 活化领域的最新进展，重点介绍了一些最有趣和最鼓舞人心的诱导反应性和选择性的例子。
