Stockmann Levin, Empel Claire
Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074, Aachen, Germany.
University of Bayreuth, Universitätsstraße 30, 95447, Bayreuth, Germany.
Chemistry. 2025 Aug 21;31(47):e01973. doi: 10.1002/chem.202501973. Epub 2025 Jul 23.
Herein, we report the palladium-catalyzed non-directed C─H functionalization reaction of simple arenes with α-trifluoromethyl styrene derivatives. The application of 2-pyridone ligands increased the yield and selectivity of the alkenylation reaction and enabled a broad scope of different simple arenes and α-trifluoromethyl styrenes (25 examples, up to 94% yield). Overall, a robust reaction is developed as described by a sensitivity screening. Detailed experimental studies on the reaction were performed to further understand the mechanism. Palladium-catalyzed non-directed C─H alkenylation of simple arenes with α-trifluoromethyl styrene derivatives is accomplished using 2-pyridone ligands, which significantly enhances both yield and selectivity. This approach enables efficient functionalization across a wide range of arenes and styrene substrates. Mechanistic studies further clarify the reaction pathway.
在此，我们报道了简单芳烃与α-三氟甲基苯乙烯衍生物的钯催化非导向C─H官能化反应。2-吡啶酮配体的应用提高了烯基化反应的产率和选择性，并适用于多种不同的简单芳烃和α-三氟甲基苯乙烯（25个实例，产率高达94%）。总体而言，如敏感性筛选所述，开发了一种稳健的反应。对该反应进行了详细的实验研究以进一步了解其机理。使用2-吡啶酮配体实现了简单芳烃与α-三氟甲基苯乙烯衍生物的钯催化非导向C─H烯基化反应，这显著提高了产率和选择性。该方法能够在广泛的芳烃和苯乙烯底物上进行高效官能化。机理研究进一步阐明了反应途径。
