Department of Pathology, Sackler School of Medicine, Tel Aviv University, Tel-Aviv, Israel, 69978.
J Pathol. 2013 Jan;229(2):198-207. doi: 10.1002/path.4103. Epub 2012 Nov 20.
Inflammation is now established as a hallmark of cancer. Cancer-associated fibroblasts (CAFs) have been established as a key component of the crosstalk between tumour cells and their microenvironment. Central to the role of CAFs in facilitating tumour growth, invasion, and metastasis is their ability to orchestrate tumour-related inflammation. CAFs and their soluble mediators provide multiple complex regulatory signals that modulate the trafficking, differentiation status, and function of inflammatory cells in the tumour microenvironment. This review focuses on pathways by which CAFs mediate tumour-promoting inflammation and modify the components of the inflammatory microenvironment that facilitate tumour initiation, progression, and metastasis.
炎症现在被确定为癌症的一个标志。癌症相关成纤维细胞（CAFs）已被确定为肿瘤细胞与其微环境之间相互作用的关键组成部分。CAFs 在促进肿瘤生长、侵袭和转移中的作用的核心是它们协调肿瘤相关炎症的能力。CAFs 及其可溶性介质提供了多种复杂的调节信号，调节肿瘤微环境中炎症细胞的迁移、分化状态和功能。本文综述了 CAFs 介导肿瘤促进炎症的途径，并修饰了促进肿瘤起始、进展和转移的炎症微环境成分。
