Institut für Biophysik und Physikalische Biochemie, Universität Regensburg, Universitätsstrasse 31, 93053 Regensburg, Germany.
Angew Chem Int Ed Engl. 2012 Oct 15;51(42):10647-51. doi: 10.1002/anie.201204148. Epub 2012 Sep 20.
Allosteric interactions: Metal(II) cyclens inhibit Ras-effector interactions by stabilizing a weak effector-binding state of Ras, state 1(T), and binding directly in the active site. The novel state (1T) inhibitor Zn(2+)-BPA (BPA = bis(2-picolyl)amine) binds outside the nucleotide binding pocket but nevertheless allosterically stabilizes state 1(T) and thus inhibits the Ras-Raf interaction.
金属(II) 环笼通过稳定 Ras 效应物结合较弱的 Ras 状态（状态 1(T)）来抑制 Ras 效应物相互作用，并直接结合在活性位点。新型的状态 1(T)抑制剂 Zn(2+)-BPA（BPA = 双(2-吡啶基)胺）结合在核苷酸结合口袋之外，但仍然变构稳定状态 1(T)，从而抑制 Ras-Raf 相互作用。
