利用加帽介孔硅纳米粒子实现衰老细胞的靶向货物递送。
Targeted cargo delivery in senescent cells using capped mesoporous silica nanoparticles.
机构信息
Centro de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Unidad Mixta Universitat Politècnica de València-Universitat de València. CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Camino de Vera s/n, 46022 Valencia (Spain).
出版信息
Angew Chem Int Ed Engl. 2012 Oct 15;51(42):10556-60. doi: 10.1002/anie.201204663. Epub 2012 Sep 20.
Learning to let go with age: Intracellular controlled release of molecules within senescent cells was achieved using mesoporous silica nanoparticles (MSNs) capped with a galacto-oligosaccharide (GOS) to contain the cargo molecules (magenta spheres; see scheme). The GOS is a substrate of the senescent biomarker, senescence-associated β-galactosidase (SA-β-gal), and releases the cargo upon entry into SA-β-gal expressing cells.
随着年龄的增长学会放手
使用被半乳糖低聚糖（GOS）覆盖的介孔硅纳米粒子（MSNs）来实现衰老细胞内分子的细胞内控制释放，以包含货物分子（品红色球体；见方案）。GOS 是衰老生物标志物，衰老相关β-半乳糖苷酶（SA-β-gal）的底物，并且在进入表达 SA-β-gal 的细胞时释放货物。
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