Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072, Australia.
Small. 2015 Nov 25;11(44):5949-55. doi: 10.1002/smll.201501449. Epub 2015 Oct 1.
A new type of monodispersed mesoporous silica nanoparticles with a core-cone structure (MSN-CC) has been synthesized. The large cone-shaped pores are formed by silica lamellae closely packed encircling a spherical core, showing a structure similar to the flower dahlia. MSN-CC has a large pore size of 45 nm and a high pore volume of 2.59 cm(3) g(-1). MSN-CC demonstrates a high loading capacity of large proteins and successfully delivers active β-galactosidase into cells, showing their potential as efficient nanocarriers for the cellular delivery of proteins with large molecular weights.
已合成出一种具有核-锥结构的新型单分散介孔硅纳米粒子（MSN-CC）。大锥形孔由紧密堆积的二氧化硅薄片围绕球形核形成，呈现出类似于大丽花的结构。MSN-CC 的孔径较大，为 45nm，孔体积高达 2.59cm³/g。MSN-CC 对大蛋白质具有高负载能力，并成功将活性β-半乳糖苷酶递送到细胞内，表明其作为具有大分子量蛋白质的细胞内递药的有效纳米载体具有潜力。
